DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and HSPA4L

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001304310.1	Gene:	HSPA4L / 22824	HGNCID:	17041	Length:	870	Species:	Homo sapiens

Alignment Length:	698	Identity:	199/698 - (28%)
Similarity:	332/698 - (47%)	Gaps:	105/698 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68
            :..||||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:|||:|:..|..|||.
Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96

  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEV-FAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAE 132
            ..|:|.||.|||..||::....|:|: ...||...::|.|..|.:.|..|:|:.|:|.|::||:|
Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161

  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ-----GTSE 192
            ..|...|.|.|:::|::|.|::|::...|..:||||.||::||.||.|:|||:.||     ....
Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226

  Fly   193 RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNK 257
            |||:..|:|...:.|.|.....|..:|.||..|.:|||.:||..||::|..||:.|:|.::.:|.
Human   227 RNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKENS 291

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKAL 321
            |||.||...||:.|:.:| :::...:.|:.....:|..:.:.||:||:|...|......|:...:
Human   292 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 356

  Fly   322 RDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSE 386
            ..|.:.:..|..|.:|||:||||.|:..:..||. |:::.::|.|||||.|.|:|.|||  ..:.
Human   357 EQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDISTTLNADEAVARGCALQCAIL--SPAF 418

  Fly   387 AVQDLLLLDVTPLSL------GIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEG 445
            .|::..:.|:.|.|:      ..|...|......|.:   |...:::. |:...:|..|...:..
Human   419 KVREFSITDLVPYSITLRWKTSFEDGSGECEVFCKNH---PAPFSKVI-TFHKKEPFELEAFYTN 479

  Fly   446 ERAMTRDNNSLGKFELSAIPPAPRG-VPQVEVTFDIDANGILNV---TALEKS------------ 494
            ...:...:..:|.|.:..:.|...| ..:|:|...::.:||.:|   :.:||.
Human   480 LHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPME 544

  Fly   495 ---------------------------------------TG---------KENRITITNDKGRLS 511
                                                   ||         |::|:..|..||::.
Human   545 TETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVK 609

  Fly   512 KEDI----------------ERMVNDAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSS 560
            ..|:                ..:.|:.:...| |:.:::|.:|||.:|.|.:..|..|...:  .
Human   610 SIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQ-DKLEKERNDAKNAVEEYVYDFRDRLGTVY--E 671

  Fly   561 RF-SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPI 606
            :| :|.|...:.....:|..|| :..:...:|.:..|.|||::...||
Human   672 KFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPI 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	199/698 (29%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	144/381 (38%)
HSPA4L	NP_001304310.1	HSPA4L_NBD	33..415	CDD:212688	145/384 (38%)
HSPA4L	NP_001304310.1	HSP70	34..725	CDD:278441	199/696 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810