DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and Hyou1

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001029200.1	Gene:	Hyou1 / 192235	RGDID:	621146	Length:	998	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	202/788 - (25%)
Similarity:	325/788 - (41%)	Gaps:	189/788 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTI 67
            |..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...|:||.:||:|......||..|:
  Rat    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    68 FDAKRLIGRRFDDATVQSDMKHWP-FEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETA 131
            ...:.|:|::.|:..|......:| .|:..:..:..:|.:...:.: |.||||..|||...|..|
  Rat    98 RYFQHLLGKQADNPHVALYRSRFPEHELNVDPQRQTVRFQISPQLQ-FSPEEVLGMVLNYSRSLA 161

  Fly   132 EAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ---GTSER 193
            |.:....:.|||:||||:||.::|:|...|..:|||.||::||:.||.|::||:.::   .::.:
  Rat   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   194 NVLIFDLGGGTFDVSVLTI------EDGI---FEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKH 249
            |::.:|:|.|:...:::|.      |.|.   .:::....|..|||.:.:.||..|..:.|..:.
  Rat   227 NIMFYDMGSGSTVCTIVTYQTVKTKEAGTQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQR 291

  Fly   250 K----KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLF 310
            |    ||:.:|.||:.:|.....|.|..||::.....:|:.|.:.|||...|||..||||..|||
  Rat   292 KGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLF 356

  Fly   311 RGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAV 375
            .....||.:||:.|:|...||..::||||:||:||||.:|......:||.|:||.|||.|.||..
  Rat   357 DRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVY 421

  Fly   376 QAAILHGDKSEAVQDLLLLD--VTPL----SLGIETAGGVMTTLIKRNTTI------PTKQTQIF 428
            |||.|  .|:..|:..::.|  :.|:    :..:|...|:.:  :|.|..:      |..|.::.
  Rat   422 QAAAL--SKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRS--LKHNKRVLFSRMGPYPQRKVI 482

  Fly   429 T------------TYAD----------------------------------------------NQ 435
            |            .|.|                                              ::
  Rat   483 TFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDE 547

  Fly   436 PGVLI-----QVF--------EGERAMTRDNNSLGKF-------------------------ELS 462
            .|||.     .||        |.|..:|:..|::...                         |.|
  Rat   548 SGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGS 612

  Fly   463 AIPPAPRG---------------VPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGR--- 509
            ...||.:|               .|..|...|....|   .|..||.:|.::.....|:||:
  Rat   613 KDEPAEQGELKEEAEAPMEDTSQPPPSEPKGDAAREG---ETPDEKESGDKSEAQKPNEKGQAGP 674

  Fly   510 ------------------------------------LSKEDIERMVNDAEAYRQADEQQRDRINA 538
                                                |.::::...|...|.....|.::::|..|
  Rat   675 EGVPPAPEEEKKQKPARKQKMVEEIGVELAVLDLPDLPEDELAHSVQKLEDLTLRDLEKQEREKA 739

  Fly   539 KNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERI 602
            .|.||::.|:.:..|.........:...||.|..:.|.|..|| |....|.....:.|..||.::
  Rat   740 ANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAELRKL 804

  Fly   603 CSPIITRL 610
            |..:..|:
  Rat   805 CQGLFFRV 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	202/788 (26%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	137/392 (35%)
Hyou1	NP_001029200.1	HSP70	35..700	CDD:278441	176/672 (26%)
		HYOU1-like_NBD	36..424	CDD:212672	135/388 (35%)
		RR_TM4-6	549..>706	CDD:283990	25/159 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..694		20/132 (15%)
		Prevents secretion from ER. /evidence=ECO:0000255	995..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810