DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and Hspa9

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_034611.2	Gene:	Hspa9 / 15526	MGIID:	96245	Length:	679	Species:	Mus musculus

Alignment Length:	642	Identity:	316/642 - (49%)
Similarity:	421/642 - (65%)	Gaps:	33/642 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTIFDA 70
            ||||||||.|||.|.:..:.:::.|.:|.|||||.|||| :.|||:|..||.|...|||||.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVF-AENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAEAY 134
            |||||||:||..||.|.|:.||::. |.||.  ..||..|  |.:.|.::.:.||.||:||||.|
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNGD--AWVEAHG--KLYSPSQIGAFVLMKMKETAENY 181

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFD 199
            ||.|..:||:||||||||||||||||||.|:||||||:||||||||:||||||  :.::.:.::|
Mouse   182 LGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDK--SEDKVIAVYD 244

  Fly   200 LGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLR 264
            |||||||:|:|.|:.|:||||:|.|||.|||||||..|:.|.|:||:|:...||.::..||:|:|
Mouse   245 LGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVR 309

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGVD----FYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325
            .|.|:||..||||.|..|.:..|.....    ....:|||:||.:..||.:.|:.|..||::||:
Mouse   310 EAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAE 374

  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390
            :.|..|.:::||||.||:||||:.:||.| |:..:|::|||||||.|||:|..:|.||    |.|
Mouse   375 VSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----VTD 434

  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455
            :||||||||||||||.|||.|.||.||||||||::|:|:|.||.|..|.|:|.:|||.|..||..
Mouse   435 VLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKL 499

  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520
            ||:|.|..||||||||||:|||||||||||::|:|.:|.||:|.:|.| ...|.|||:|||.||.
Mouse   500 LGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVI-QSSGGLSKDDIENMVK 563

  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDD--EHLSSRFSPADR-ETIQQRSSETIAWLD 582
            :||.|.:.|.::::|:.|.|..|.......:.:::  :.|     |||. ..:::..|:..|.|.
Mouse   564 NAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQL-----PADECNKLKEEISKMRALLA 623

  Fly   583 ANQLAERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGGSNPGATGGSGPTIEE 639
            .......:........|::....:....|:  .||......||:     |:|...|:
Mouse   624 GKDSETGENIRQAASSLQQASLKLFEMAYK--KMASEREGSGSS-----GTGEQKED 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	316/642 (49%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	202/379 (53%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250\|UniProtKB:P38646	1..432		205/386 (53%)
		dnaK	52..673	CDD:234715	315/640 (49%)
		HSPA9-like_NBD	52..428	CDD:212683	202/378 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250\|UniProtKB:P38646	432..679		111/255 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	656..679		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820