DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and Hspa4

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	703	Identity:	208/703 - (29%)
Similarity:	340/703 - (48%)	Gaps:	104/703 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68
            :..||||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.||.|||:||..|..||:.
Mouse     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEVF-AENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAE 132
            ..||..||.|.|..|:::..:..:::. ...|...|:|.|..|.::|..|:|::|:|:|::||||
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG-----TSE 192
            :.|...|.|.||:||:::.|::|::..||..|||||.||::||.||.|:|||:.||.     ...
Mouse   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   193 RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNK 257
            |||:..|:|...:.|||.....|..:|.|||.||.|||..||..|||||.:||.:|:|.|:....
Mouse   196 RNVVFVDMGHSAYQVSVCAFNKGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260

  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKAL 321
            |||.||...||:.|:.:| :::...:.|:.....:|...::.|.:|.|:..||......|:...|
Mouse   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSVL 325

  Fly   322 RDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSE 386
            ..:|:.|..|:.:.:|||:||||.|:..:..|| ||||:.::|.||||..|.|:|.|||  ..:.
Mouse   326 EQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAIL--SPAF 387

  Fly   387 AVQDLLLLDVTPLSLGIE-----TAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGE 446
            .|::..:.||.|..:.:.     ..|.....:..:|...|.  :::.|.|. .:|..|...:...
Mouse   388 KVREFSITDVVPYPISLRWNSPAEEGLSDCEVFPKNHAAPF--SKVLTFYR-KEPFTLEAYYSSP 449

  Fly   447 RAMTRDNNSLGKFELSAIPPAPRG-VPQVEVTFDIDANGILNVTA---LEKSTGKENRITITNDK 507
            :.:...:.::.:|.:..:.|...| ..:|:|...::.:||.:|::   :|....:|:...:..|:
Mouse   450 QDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQ 514

  Fly   508 GRLSKEDIERMVNDAEAYRQADEQQ---------------------------------------- 532
            .  :||:.:..|:..|.:.:..:||
Mouse   515 N--AKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTS 577

  Fly   533 ------------------------------------RDRINAKNQLESYCFQLRSTLDDEHLSSR 561
                                                ::|.:|||.:|.|.:::|..|..|:  .:
Mouse   578 TVDLPIESQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEY--EK 640

  Fly   562 F-SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPIITRLYQ 612
            | |..||.|...:..:|..|| :..:...:|.:..|..||:.:..||.||..:
Mouse   641 FVSEDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQE 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	208/703 (30%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	154/381 (40%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	155/384 (40%)
		HSP70	3..609	CDD:278441	183/613 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		8/78 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810