Protein Alignment Hsc70-1 and Hspa1b

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_034608.2
• Gene: Hspa1b / 15511
• MGIID: 99517
• Length: 642
• Species: Mus musculus
• Alignment Length: 645
• Identity: 510/645 - (79%)
• Similarity: 574/645 - (88%)
• Gaps: 7/645 - (1%)

  Fly     1 MPKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNN 65
            |.|..|:||||||||||||||||||||||||||||||||||||||::|||||||||||||:||.|
Mouse     1 MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65

  Fly    66 TIFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRET 130
            |:|||||||||:|.||.||||||||||:|..:..||:::|.||||.:||:|||:||||||||:|.
Mouse    66 TVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEI 130

  Fly   131 AEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNV 195
            ||||||..||:||:||||||||||||||||||.|||||||||||||||||||||||:.|..||||
Mouse   131 AEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195

  Fly   196 LIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRAL 260
            |||||||||||||:|||:|||||||||||||||||||||||||:|||:||:||||||:.|||||:
Mouse   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325
            |||||||||||||||||||||:||||||||:|||||:||||||||..||||||:|||.|||||||
Mouse   261 RRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAK 325

  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390
            |||.||||:|||||||||||||:||||||||::||||||||||||||||||||||.|||||.|||
Mouse   326 MDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQD 390

  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455
            ||||||.|||||:||||||||.|||||:||||||||.||||:||||||||||:|||||||||||.
Mouse   391 LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNL 455

  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520
            ||:||||.||||||||||:||||||||||||||||.:|||||.|:|||||||||||||:|||||.
Mouse   456 LGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQ 520

  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585
            :||.|:..||.||||:.|||.||||.|.::|.::||.|..:.|.||::.:..:..|.|:|||:|.
Mouse   521 EAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNT 585

  Fly   586 LAERQEFEHKQQELERICSPIITRLYQGAGMAPPPTAGG----SNPGATGGSGPTIEEVD 641
            ||:::||.||::||||:|||||:.||||||   .|.|||    :.|....||||||||||
Mouse   586 LADKEEFVHKREELERVCSPIISGLYQGAG---APGAGGFGAQAPPKGASGSGPTIEEVD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	508/643 (79%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	320/374 (86%)
Hspa1b	NP_034608.2	PTZ00009	1..642	CDD:240227	508/643 (79%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		325/383 (85%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	320/374 (86%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		99/114 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	617..642		13/24 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm42402
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730