DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-1 and Hspa5

DIOPT Version :9

Sequence 1:NP_524063.1 Gene:Hsc70-1 / 39542 FlyBaseID:FBgn0001216 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_001156906.1 Gene:Hspa5 / 14828 MGIID:95835 Length:655 Species:Mus musculus


Alignment Length:618 Identity:390/618 - (63%)
Similarity:500/618 - (80%) Gaps:8/618 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-ESERLIGDAAKNQVAMNPNNTIFDA 70
            |||||||||||||||::|:|||||||||||.|||||||| |.|||||||||||:..||.||:|||
Mouse    32 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 96

  Fly    71 KRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEY-KGERKSFYPEEVSSMVLTKMRETAEAY 134
            ||||||.::|.:||.|:|..||:|..:..||.|:|:. .|:.|:|.|||:|:||||||:||||||
Mouse    97 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 161

  Fly   135 LGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNVLIFD 199
            ||..||.|||||||||||:|||||||||.||||||:|||||||||||||||||: ..|:|:|:||
Mouse   162 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 225

  Fly   200 LGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLR 264
            |||||||||:|||::|:|||.||.|||||||||||.|::.||::.:::|..||:.::.||:::||
Mouse   226 LGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLR 290

  Fly   265 TACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKG 329
            ...|:|||.|||..||.|||:|.|||.||..::|||:|||||.||||.||:||.|.|.|:.:.|.
Mouse   291 REVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKS 355

  Fly   330 QIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLL 394
            .|.:||||||||||||:|:|:::||||||.::.|||||||||||||||.:|.||:...  ||:||
Mouse   356 DIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG--DLVLL 418

  Fly   395 DVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKF 459
            ||.||:|||||.|||||.||.|||.:|||::|||:|.:||||.|.|:|:||||.:|:||:.||.|
Mouse   419 DVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTF 483

  Fly   460 ELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVNDAEA 524
            :|:.||||||||||:||||:||.||||.|||.:|.||.:|:||||||:.||:.|:|||||||||.
Mouse   484 DLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEK 548

  Fly   525 YRQADEQQRDRINAKNQLESYCFQLRSTL-DDEHLSSRFSPADRETIQQRSSETIAWLDANQLAE 588
            :.:.|::.::||:.:|:||||.:.|::.: |.|.|..:.|..|:||:::...|.|.||:::|.|:
Mouse   549 FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDAD 613

  Fly   589 RQEFEHKQQELERICSPIITRLYQGAGMAPPPT 621
            .::|:.|::|||.|..|||::||...|  ||||
Mouse   614 IEDFKAKKKELEEIVQPIISKLYGSGG--PPPT 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-1NP_524063.1 PTZ00009 1..641 CDD:240227 390/618 (63%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 256/375 (68%)
Hspa5NP_001156906.1 Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021 1..81 42/48 (88%)
HSP70 31..636 CDD:365808 383/606 (63%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 126..281 110/155 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 410..420 4/11 (36%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 421..501 53/79 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655 8/15 (53%)
Prevents secretion from ER 652..655
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.720

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