DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-1 and Hyou1

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_067370.3	Gene:	Hyou1 / 12282	MGIID:	108030	Length:	999	Species:	Mus musculus

Alignment Length:	792	Identity:	201/792 - (25%)
Similarity:	328/792 - (41%)	Gaps:	197/792 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPAVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTI 67
            |..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...|:||.:||:|......||..|:
Mouse    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    68 FDAKRLIGRRFDDATVQSDMKHWP-FEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETA 131
            ...:.|:|::.|:..|......:| .|:..:..:..:|.:...:.: |.||||..|||...|..|
Mouse    98 RYFQHLLGKQADNPHVALYRSRFPEHELIVDPQRQTVRFQISPQLQ-FSPEEVLGMVLNYSRSLA 161

  Fly   132 EAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ---GTSER 193
            |.:....:.|||:||||:||.::|:|...|..:|||.||::||:.||.|::||:.::   .::.:
Mouse   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   194 NVLIFDLGGGTFDVSVLTI------EDGI---FEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKH 249
            ||:.:|:|.|:...:::|.      |.|:   .:::....|..|||.:.:.||..|..:.|..:.
Mouse   227 NVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQR 291

  Fly   250 K----KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLF 310
            |    ||:.:|.||:.:|.....|.|..||::.....:|:.|.:.|||...|||..||||..|||
Mouse   292 KGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLF 356

  Fly   311 RGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAV 375
            .....||.:||:.|:|...||..::||||:||:||||.:|......:||.|:||.|||.|.||..
Mouse   357 DRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVY 421

  Fly   376 QAAILHGDKSEAVQDLLLLD--VTPL----SLGIETAGGVMTTLIKRNTTI------PTKQTQIF 428
            |||.|  .|:..|:..::.|  :.|:    :..:|...|:.:  :|.|..:      |..|.::.
Mouse   422 QAAAL--SKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRS--LKHNKRVLFSRMGPYPQRKVI 482

  Fly   429 T------------TYAD----------------------------------------------NQ 435
            |            .|.|                                              ::
Mouse   483 TFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDE 547

  Fly   436 PGVLI-----QVF--------EGERAMTRDNNSL------------------------------- 456
            .|||.     .||        |.|..:|:..|::
Mouse   548 SGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGS 612

  Fly   457 -------GKFELSAIPPA------PRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKG 508
                   |:.:..|.|||      |...|:.:...:.:...       ||.:|.:......|:||
Mouse   613 KDEPAEQGELKEEAEPPAEETSQPPPSEPKGDAAREGEKPD-------EKESGDKPEAQKPNEKG 670

  Fly   509 R---------------------------------------LSKEDIERMVNDAEAYRQADEQQRD 534
            :                                       |.::::.|.|...|.....|.::::
Mouse   671 QAGPEGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDLEKQE 735

  Fly   535 RINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQE 598
            |..|.|.||::.|:.:..|.........:...||.|..:.|.|..|| |....|.....:.|..|
Mouse   736 REKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAE 800

  Fly   599 LERICSPIITRL 610
            |.::|..:..|:
Mouse   801 LRKLCQGLFFRV 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	201/792 (25%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	138/392 (35%)
Hyou1	NP_067370.3	HYOU1-like_NBD	36..424	CDD:212672	136/388 (35%)
		MDN1	<554..767	CDD:227596	31/219 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..694		17/133 (13%)
		PHA03169	<586..>691	CDD:223003	13/111 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810