Protein Alignment Hsc70-1 and Hyou1

DIOPT Version :10

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_067370.3
• Gene: Hyou1 / 12282
• MGIID: 108030
• Length: 999
• Species: Mus musculus
• Alignment Length: 792
• Identity: 201/792 - (25%)
• Similarity: 328/792 - (41%)
• Gaps: 197/792 - (24%)

  Fly     4 LPAVGIDLGTTYSCVGVFQHG-KVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTI 67
            |..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...|:||.:||:|......||..|:
Mouse    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    68 FDAKRLIGRRFDDATVQSDMKHWP-FEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETA 131
            ...:.|:|::.|:..|......:| .|:..:..:..:|.:...:.: |.||||..|||...|..|
Mouse    98 RYFQHLLGKQADNPHVALYRSRFPEHELIVDPQRQTVRFQISPQLQ-FSPEEVLGMVLNYSRSLA 161

  Fly   132 EAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQ---GTSER 193
            |.:....:.|||:||||:||.::|:|...|..:|||.||::||:.||.|::||:.::   .::.:
Mouse   162 EDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINSTAQ 226

  Fly   194 NVLIFDLGGGTFDVSVLTI------EDGI---FEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKH 249
            ||:.:|:|.|:...:::|.      |.|:   .:::....|..|||.:.:.||..|..:.|..:.
Mouse   227 NVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKLFNEQR 291

  Fly   250 K----KDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLF 310
            |    ||:.:|.||:.:|.....|.|..||::.....:|:.|.:.|||...|||..||||..|||
Mouse   292 KGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLF 356

  Fly   311 RGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAV 375
            .....||.:||:.|:|...||..::||||:||:||||.:|......:||.|:||.|||.|.||..
Mouse   357 DRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADEAAAMGAVY 421

  Fly   376 QAAILHGDKSEAVQDLLLLD--VTPL----SLGIETAGGVMTTLIKRNTTI------PTKQTQIF 428
            |||.|  .|:..|:..::.|  :.|:    :..:|...|:.:  :|.|..:      |..|.::.
Mouse   422 QAAAL--SKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRS--LKHNKRVLFSRMGPYPQRKVI 482

  Fly   429 T------------TYAD----------------------------------------------NQ 435
            |            .|.|                                              ::
Mouse   483 TFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYESKGIKAHFNLDE 547

  Fly   436 PGVLI-----QVF--------EGERAMTRDNNSL------------------------------- 456
            .|||.     .||        |.|..:|:..|::
Mouse   548 SGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQEEEESPAEGS 612

  Fly   457 -------GKFELSAIPPA------PRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKG 508
                   |:.:..|.|||      |...|:.:...:.:...       ||.:|.:......|:||
Mouse   613 KDEPAEQGELKEEAEPPAEETSQPPPSEPKGDAAREGEKPD-------EKESGDKPEAQKPNEKG 670

  Fly   509 R---------------------------------------LSKEDIERMVNDAEAYRQADEQQRD 534
            :                                       |.::::.|.|...|.....|.::::
Mouse   671 QAGPEGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDLEKQE 735

  Fly   535 RINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQE 598
            |..|.|.||::.|:.:..|.........:...||.|..:.|.|..|| |....|.....:.|..|
Mouse   736 REKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKDKLAE 800

  Fly   599 LERICSPIITRL 610
            |.::|..:..|:
Mouse   801 LRKLCQGLFFRV 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	201/792 (25%)
Hyou1	NP_067370.3	ASKHA_NBD_HSP70_HYOU1	34..424	CDD:466828	136/390 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	567..694		17/133 (13%)
		PHA03169	<586..>691	CDD:223003	13/111 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999