DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-1 and HSPA12B

DIOPT Version :9

Sequence 1:	NP_524063.1	Gene:	Hsc70-1 / 39542	FlyBaseID:	FBgn0001216	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_443202.3	Gene:	HSPA12B / 116835	HGNCID:	16193	Length:	686	Species:	Homo sapiens

Alignment Length:	652	Identity:	134/652 - (20%)
Similarity:	222/652 - (34%)	Gaps:	188/652 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGIDLGTTYSCVGVFQHGKVEII-------ANDQG--NRTTPSYVAFTESERL--IGDAAKNQV- 59
            |.||.|||.|..........|.|       ..|.|  ::.||:.:..|.....  .|..|::..
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGAFHSFGYTARDYYH 127

  Fly    60 AMNPNNT----IFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVS 120
            .::|...    .|:..::......|.|:::.::       |.|||....:|.......|:.|.
Human   128 DLDPEEARDWLYFEKFKMKIHSATDLTLKTQLE-------AVNGKTMPALEVFAHALRFFREH-- 183

  Fly   121 SMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGL------NVLRIINEPTAA 179
              .|.::||.:.:.........|:||||.:....:|..::|..:|||      ..|.|..||.||
Human   184 --ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEPEAA 246

  Fly   180 AI----------------AYG------------------------------LDKQGTSE------ 192
            ::                |.|                              |.:.|..|
Human   247 SVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQ 311

  Fly   193 --RNVLIFDLGGGTFDVSVLTIED--GIFE--VKATAGDTHLGGED--FDNRLVNHFVQEFQRKH 249
              ...::.|.||||.|::|..:|.  |..:  .||:.|.....|.|  |:..|...|.::|....
Human   312 AGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIATF 376

  Fly   250 KKDLGQNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGVDFY---------TSVTRARFE-- 303
            |:   |...|...|..|.|..|||.......::.|...|..:|||         |::.|:...
Human   377 KR---QRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFV 438

  Fly   304 ------------ELNGDLFRGTMEPVAKALRDAKMDKGQIHDI---VLVGGSTRIPKVQRLLQDF 353
                        |...:||:.|:..:.:.: :|.:.:.::..:   .||||......:|..:|..
Human   439 KWSSQGMLRMSCEAMNELFQPTVSGIIQHI-EALLARPEVQGVKLLFLVGGFAESAVLQHAVQAA 502

  Fly   354 FNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGIETAGGVMTTLIKRNT 418
            ...:.|...:..|..:   ..::.|:|.|.....|:    :..:||:.|:    ||:      |.
Human   503 LGARGLRVVVPHDVGL---TILKGAVLFGQAPGVVR----VRRSPLTYGV----GVL------NR 550

  Fly   419 TIPTKQ--------------TQIF-----------------TTYADNQPG---VLIQVF----EG 445
            .:|.:.              |.:|                 .:|...:||   |||.::    |.
Human   551 FVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAED 615

  Fly   446 ERAMTRDN-NSLGKFELSAIPP--------APRGVPQVEVTFDIDANGILNVTALEKSTGKENRI 501
            .|.:|... ...|...|...|.        ||.|..::..........| .|||::.||.:..|.
Human   616 ARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTEI-KVTAVDVSTNRSVRA 679

  Fly   502 TI 503
            :|
Human   680 SI 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	134/652 (21%)
Hsc70-1	NP_524063.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	99/481 (21%)
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..53
HSPA12B	NP_443202.3	NBD_sugar-kinase_HSP70_actin	61..529	CDD:327376	100/483 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810