Protein Alignment Hsc70-1 and HSPH1

DIOPT Version :9

• Sequence 1: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 195/710 - (27%)
• Similarity: 312/710 - (43%)
• Gaps: 164/710 - (23%)

  Fly    40 SYVAFTESERLIGDAAKNQVAMNPNNTIFDAKRLIGRRFDDATVQSDMKHWPFE-VFAENGKPRI 103
            |.::|....|.||.|||||...:.|||:.:.||..||.|:|..:|.:.::..:: |..:||...|
Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGI 103

  Fly   104 RVEYKGERKSFYPEEVSSMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLN 168
            :|.|.||...|..|::::|:|||::||||..|...|||.|::||::|.|::|::..||..|.|||
Human   104 KVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 168

  Fly   169 VLRIINEPTAAAIAYGLDKQ-----GTSERNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHL 228
            .||::|:.||.|:.||:.||     ....|.|:..|:|...|.||......|..:|..||.|..|
Human   169 CLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFL 233

  Fly   229 GGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRTACERAKRTLSS-STQASIEIDSLFEGVD 292
            ||::||.:||.||..||:.|:|.|.....|||.||...||:.|:.:|| ||...:.|:......|
Human   234 GGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKD 298

  Fly   293 FYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGK 357
            ....:.|::||||..:|.:....|:...|....:....:..:.:|||:||||.|:..:..|| ||
Human   299 VSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-GK 362

  Fly   358 ELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGI-------ETAGGVMTTLIK 415
            :::.::|.|||||.|.|:|.|||  ..:..|::..:.|..|..:.:       :|.|  :..:..
Human   363 DISTTLNADEAVARGCALQCAIL--SPAFKVREFSVTDAVPFPISLIWNHDSEDTEG--VHEVFS 423

  Fly   416 RNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFELSAIPPAPRGVP-------- 472
            ||...|..:...|                    :.|     |.|||.|....|:|||
Human   424 RNHAAPFSKVLTF--------------------LRR-----GPFELEAFYSDPQGVPYPEAKIGR 463

  Fly   473 ---------------QVEVTFDIDANGILNVTA---LEKSTGKENRITITNDKGRLSKE-----D 514
                           :|:|...::.:||..::.   :||...:||.::...|...|::.     |
Human   464 FVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPD 528

  Fly   515 IERMV--------------NDAEAYRQA------------------------------------- 528
            .::.|              .||:...|:
Human   529 TDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKV 593

  Fly   529 ---------------------------------DEQQRDRINAKNQLESYCFQLRSTLDDEHLSS 560
                                             |:.:::|.:|||.:|.|.::.|..|...:  .
Human   594 VNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPY--E 656

  Fly   561 RF-SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPIITRLYQGAGMAP 618
            :| ...|.:...:..:||..|| :..:...:|.:..|.:||.:|.:|:..| :|.|...|
Human   657 KFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVR-FQEAEERP 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	195/710 (27%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	135/347 (39%)
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	136/349 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810