DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and TFIIIA

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001322779.1	Gene:	TFIIIA / 843536	AraportID:	AT1G72050	Length:	427	Species:	Arabidopsis thaliana

Alignment Length:	415	Identity:	95/415 - (22%)
Similarity:	164/415 - (39%)	Gaps:	98/415 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALAR 257
            :|.|.:::.|::|:.:::..|..              :.:...:.::.||..||:|.|....:.:
plant     2 EEINPSSSVDNKRDMAEEAKVDV--------------KTSAKKDIRNYLCQYCGISRSKNYLITK 52

  Fly   258 HVAKH------KEQGD--------TQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPL--CP 306
            |:..|      :|:.|        :...|.|..||..|:..|.|..|.:.|:.||.|.|.:  |.
plant    53 HIQSHHQMELEEERDDEACEVDEESSSNHTCQECGAEFKKPAHLKQHMQSHSLERSFTCYVDDCA 117

  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQ--CDKTFYTRGNLRAHIQRH--------------TGERP 355
            .:|.....|..|:.|| :.|..|||:  |...|..:||:..|::::              .|::.
plant   118 ASYRRKDHLNRHLLTH-KGKLFKCPKENCKSEFSVQGNVGRHVKKYHSNDNRDKDNTGLGDGDKD 181

  Fly   356 YKCP-----------DCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGD 409
            ..|.           .|.:....|.|....:..:.:.:|.:|.                   .|.
plant   182 NTCKGDDDKEKSGSGGCEKENEGNGGSGKDNNGNGDSQPAECS-------------------TGQ 227

  Fly   410 RQFKCPD--CDKSFFEKSNMMKHQRTH---SGIKPFKCEE--CGQAFSHNHHLKSHLRIHTGEKP 467
            :|..|.:  |.|:|...|.:.|||.:|   ..::.| |.|  |.:.|::...||||:|  :..:.
plant   228 KQVVCKEIGCGKAFKYPSQLQKHQDSHVKLDSVEAF-CSEPGCMKYFTNEECLKSHIR--SCHQH 289

  Fly   468 YKCDQCGKGFSANQSLMKHTLWHVDNNDRP--FKC--SQCPKAYDTQQSLRGHEKTHKNPDEPKT 528
            ..|:.||.. ...:::.:|...| |.:..|  .||  ..|...:....:|:.|.|...:...|
plant   290 INCEICGSK-HLKKNIKRHLRTH-DEDSSPGEIKCEVEGCSSTFSKASNLQKHMKAVHDDIRP-- 350

  Fly   529 LHQC--PHCDVRFALKKTLDKHITS 551
             ..|  |.|.:|||.|...:||..|
plant   351 -FVCGFPGCGMRFAYKHVRNKHENS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	9/25 (36%)
		C2H2 Zn finger	302..322	CDD:275368	5/21 (24%)
		C2H2 Zn finger	330..350	CDD:275368	7/21 (33%)
		zf-H2C2_2	342..366	CDD:290200	5/48 (10%)
		C2H2 Zn finger	358..378	CDD:275368	4/30 (13%)
		C2H2 Zn finger	386..406	CDD:275368	1/19 (5%)
		COG5048	<395..583	CDD:227381	45/170 (26%)
		zf-C2H2	412..434	CDD:278523	8/23 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/21 (38%)
		zf-H2C2_2	426..451	CDD:290200	9/29 (31%)
		C2H2 Zn finger	442..462	CDD:275368	9/21 (43%)
		zf-H2C2_2	454..478	CDD:290200	8/23 (35%)
		C2H2 Zn finger	470..486	CDD:275368	3/15 (20%)
		C2H2 Zn finger	500..520	CDD:275368	5/21 (24%)
		C2H2 Zn finger	532..552	CDD:275370	10/22 (45%)
		C2H2 Zn finger	559..579	CDD:275370
TFIIIA	NP_001322779.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050