DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and zgc:171673

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_005168174.1	Gene:	zgc:171673 / 797138	ZFINID:	ZDB-GENE-071004-20	Length:	366	Species:	Danio rerio

Alignment Length:	416	Identity:	136/416 - (32%)
Similarity:	200/416 - (48%)	Gaps:	87/416 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESEPLQEVFEITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWI 224
            :|||           |:|..:.|:|:  :||. :|:.|                 |.|.::||
Zfish     6 EESE-----------DVKIIEMVTIK--YEDP-EEQAD-----------------SVEPKEEP-- 37

  Fly   225 PGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPH----------------- 272
                         |.|:..|......||:.||           |::||
Zfish    38 -------------QELIEMEEKHQCETQQVLA-----------TEEPHTEATQTSPRTSKSPQKS 78

  Fly   273 ------LCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCP 331
                  :|..||:.|.....|..|...|.||:|:.|..|.|::...|.|:.||..|..||.:.|.
Zfish    79 KPSSLFICCQCGKSFTRKQSLEGHMNLHNGEKPYSCQQCGKSFRQKPNLRVHMRVHTGEKPYTCK 143

  Fly   332 QCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQN 396
            ||.|:|......:.|::.||||:||.|..|.:.|::.|....|:|:|..|:|:.|:||||.|...
Zfish   144 QCGKSFSLVQGYKIHMRSHTGEKPYVCQQCGKGFSQISSFNSHTRIHTREKPYSCQLCGKDFSIK 208

  Fly   397 QHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRI 461
            |||..|:.:|:.::.|:|..|.|:||.|.::.||.|.|||.|.|.|:.||.:|:..:.||.|:||
Zfish   209 QHLNDHMIIHSAEKAFECQQCGKTFFLKRHLKKHIRVHSGEKNFTCQLCGNSFTQMYSLKRHMRI 273

  Fly   462 HTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEP 526
            |:|||||.|.||||.|:.|.||..|...|   .:|.|.|.:|.::::.:..|..|.|||   .|.
Zfish   274 HSGEKPYSCQQCGKRFTQNNSLDIHVRTH---TERSFTCQECGESFNLKSDLNNHVKTH---GEE 332

  Fly   527 KTLHQCPHCDVRFALKKTLDKHITSH 552
            |.. .|..|:..|:.|..|::|:.:|
Zfish   333 KAF-PCGQCEKSFSRKDNLNRHMRAH 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		COG5048	<395..583	CDD:227381	64/158 (41%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	16/23 (70%)
		C2H2 Zn finger	470..486	CDD:275368	9/15 (60%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370
zgc:171673	XP_005168174.1	COG5048	67..>360	CDD:227381	111/298 (37%)
		C2H2 Zn finger	86..106	CDD:275368	6/19 (32%)
		zf-C2H2	112..134	CDD:278523	7/21 (33%)
		C2H2 Zn finger	114..134	CDD:275368	7/19 (37%)
		zf-H2C2_2	126..150	CDD:290200	10/23 (43%)
		C2H2 Zn finger	142..162	CDD:275368	6/19 (32%)
		zf-H2C2_2	156..179	CDD:290200	10/22 (45%)
		C2H2 Zn finger	170..190	CDD:275368	6/19 (32%)
		C2H2 Zn finger	198..218	CDD:275368	10/19 (53%)
		C2H2 Zn finger	226..246	CDD:275368	9/19 (47%)
		zf-H2C2_2	238..263	CDD:290200	12/24 (50%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..291	CDD:290200	17/24 (71%)
		C2H2 Zn finger	282..302	CDD:275368	10/19 (53%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		zf-C2H2	335..357	CDD:278523	6/22 (27%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900