DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and zgc:175107

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001107104.1	Gene:	zgc:175107 / 794317	ZFINID:	ZDB-GENE-080220-38	Length:	333	Species:	Danio rerio

Alignment Length:	356	Identity:	115/356 - (32%)
Similarity:	178/356 - (50%)	Gaps:	31/356 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 IKTEDE-VSIQETF----EDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGG 235
            ||.|.| :.|:.||    ||. |::.|......||:::::....:..|:.:..|    |.::...
Zfish     4 IKEESEDLKIEHTFTVKHEDR-DKQTDLTAPKVERQETNELEERNQYDKRDSAI----GEKSTHT 63

  Fly   236 NNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPF 300
            .:.|||                   |..:..::...::|..|.:.|.....|..|:|.||||:||
Zfish    64 QDASLL-------------------KRPQSAESSGYYICGECNKSFGLKQNLEVHKRTHTGEKPF 109

  Fly   301 KCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTF 365
            .|..|.|:::....||.||..|..||...||.|.:.|..:|||:.|::.||||..:.|..|.::|
Zfish   110 SCQQCGKSFSQKQNLKVHMRVHTGEKPFSCPFCGQNFTHKGNLKTHVRNHTGESAFICNLCGKSF 174

  Fly   366 AKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKH 430
            ::...|..|.|:|..|:||.|..|||.|....:|..|:|:|:.:..|.|..|::||.:...:..|
Zfish   175 SRKESLNTHMRIHSGEKPFGCAQCGKTFRCKVNLNCHMRIHSRESSFICHHCEQSFGDSDELRSH 239

  Fly   431 QRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNND 495
            ..||.|.|||.|..||::.|:...|:.|.||||||:|:.|.||||.|:...:|..|.  .|...:
Zfish   240 VNTHVGEKPFMCLHCGKSCSNKAVLEVHSRIHTGERPFVCPQCGKSFTLRGNLNIHI--RVHTGE 302

  Fly   496 RPFKCSQCPKAYDTQQSLRGHEKTHKNPDEP 526
            :||.|..|.|::.....|:.|.::....:.|
Zfish   303 KPFNCVHCEKSFTYHTDLKRHLQSPCEKNSP 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	0/19 (0%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	46/132 (35%)
		zf-C2H2	412..434	CDD:278523	6/21 (29%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..451	CDD:290200	10/24 (42%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	14/23 (61%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
zgc:175107	NP_001107104.1	C2H2 Zn finger	83..103	CDD:275368	6/19 (32%)
		zf-H2C2_2	95..120	CDD:290200	12/24 (50%)
		COG5048	<107..286	CDD:227381	73/178 (41%)
		C2H2 Zn finger	111..131	CDD:275368	7/19 (37%)
		zf-H2C2_2	123..148	CDD:290200	11/24 (46%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		zf-C2H2	165..187	CDD:278523	6/21 (29%)
		C2H2 Zn finger	167..187	CDD:275368	6/19 (32%)
		C2H2 Zn finger	195..215	CDD:275368	8/19 (42%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		zf-H2C2_2	264..287	CDD:290200	14/22 (64%)
		C2H2 Zn finger	279..299	CDD:275368	8/21 (38%)
		zf-H2C2_2	291..316	CDD:290200	8/26 (31%)
		C2H2 Zn finger	307..324	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810