DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and Zfp872

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001028985.1	Gene:	Zfp872 / 619310	MGIID:	3588272	Length:	465	Species:	Mus musculus

Alignment Length:	335	Identity:	118/335 - (35%)
Similarity:	180/335 - (53%)	Gaps:	11/335 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306
            |.:||.::|.|.:...|...|    ..:||::|..||:.|..:.....|.|.||||:|:||..|.
Mouse   140 CKDCGKAFSFQSSFRIHERTH----TGEKPYMCKECGKAFIYHTTYQGHMRMHTGEKPYKCKECG 200

  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGL 371
            ||::|....::|...|..||.::|.||.|||......:.|.:.||||:||:|..|.:..::::..
Mouse   201 KAFSHPSLFRNHERAHSGEKPYECKQCGKTFRYYQTFQLHERTHTGEKPYQCKQCGKALSRSTSF 265

  Fly   372 KLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSG 436
            :.|.|:|..|:|:||..|||.|........|.|:|..:|.:.|.:|.|:|....:..:|...|:|
Mouse   266 RSHERIHTGEKPYKCRKCGKAFRFPSSFRKHERIHTDERPYDCKECGKAFISLPSFRRHVILHTG 330

  Fly   437 IKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCS 501
            ..|:||:|||:||........|.|.||||||::|.:|||.||...|:..|...|  ..::|::|.
Mouse   331 NGPYKCKECGKAFDCPSSFHIHERTHTGEKPHECQRCGKAFSCASSVRIHERTH--TGEKPYECK 393

  Fly   502 QCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEG 565
            ||.||:.:..|.|.||:.|.. ::|   ::|..|...|:...:...|..:|| .:|:.|.||.:.
Mouse   394 QCGKAFSSSSSFRMHERIHTG-EKP---YECRQCGKAFSFSSSFRMHERTHKGEKPYECKQCGKA 454

  Fly   566 FFSQKSLKKH 575
            |.|..|...|
Mouse   455 FSSSSSFHMH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	4/19 (21%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	62/182 (34%)
		zf-C2H2	412..434	CDD:278523	5/21 (24%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		C2H2 Zn finger	532..552	CDD:275370	4/19 (21%)
		C2H2 Zn finger	559..579	CDD:275370	7/17 (41%)
Zfp872	NP_001028985.1	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	78..94	CDD:275368
		C2H2 Zn finger	102..122	CDD:275368
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		zf-H2C2_2	152..177	CDD:290200	8/28 (29%)
		COG5048	164..>449	CDD:227381	104/290 (36%)
		C2H2 Zn finger	168..188	CDD:275368	6/19 (32%)
		zf-H2C2_2	184..205	CDD:290200	12/20 (60%)
		C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		C2H2 Zn finger	224..244	CDD:275368	7/19 (37%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..287	CDD:290200	10/22 (45%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		zf-H2C2_2	376..401	CDD:290200	9/26 (35%)
		C2H2 Zn finger	392..412	CDD:275368	9/19 (47%)
		zf-H2C2_2	404..428	CDD:290200	8/27 (30%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000