DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and znf1068

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001104669.1	Gene:	znf1068 / 569852	ZFINID:	ZDB-GENE-080215-12	Length:	419	Species:	Danio rerio

Alignment Length:	429	Identity:	155/429 - (36%)
Similarity:	230/429 - (53%)	Gaps:	30/429 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESE--PLQEVFEITMNDIKTEDEVSI--QETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQD 220
            :|||  .::|.|.:...|::.:.::.:  :||.:....||...........|........|..:.
Zfish     6 EESEDVKIEETFTVKQEDLQEQTDLMVLKEETHQQNKMEEKQFEKHQETTTDEKPTLTKKTSSRR 70

  Fly   221 EPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNA 285
            .|       |::....|  |.|.:||..:..:..|..|:..|    ..:||:.|..||:.|.|:.
Zfish    71 RP-------RKSESACN--LTCRQCGNRFRRKHNLQIHMRIH----TGEKPYTCQQCGQCFCTSG 122

  Fly   286 QLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRH 350
            .|..|.|.||||:|:.||.|.|::.|...||.||.||..|:.:.|.||.:.|||.|||.||::.|
Zfish   123 NLVVHMRLHTGEKPYSCPQCGKSFKHNGNLKVHMRTHTGERPYTCQQCGQCFYTTGNLAAHMRIH 187

  Fly   351 TGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCP 415
            ||||||.|..|.::|.:::.|..|.|:|..|||:.|:.|||.|.|:.:|:.|:|:|.|:|.:.||
Zfish   188 TGERPYTCQQCGKSFYQSANLAAHMRIHTGERPYTCQQCGKSFYQSANLVVHMRIHTGERPYSCP 252

  Fly   416 DCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSAN 480
            .|.|||.:.||:..|.|||:|.:.|.|.:||::|:....|..|:|||||||||.|.:|||.|...
Zfish   253 QCGKSFKQNSNLEAHIRTHNGGRSFTCPQCGKSFAQKQDLDLHMRIHTGEKPYTCTECGKSFRCK 317

  Fly   481 QSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTL 545
            .:|..|.:.|  ..::||.|:||.|::.|:.||:.|...|..    ..:..|..|......|.|:
Zfish   318 SALNNHMISH--TGEKPFTCAQCGKSFTTKTSLKNHMNGHTG----TIVFTCDQCGKSLTRKDTI 376

  Fly   546 DKHITSHK----IRPHPCPQCPEGFFSQKSLKKHLRLHN 580
            ..|:.:|.    .|   |.:|.:||..:|||..|::|||
Zfish   377 RNHMKTHSGEDGFR---CSECGKGFKYKKSLNTHIKLHN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	9/19 (47%)
		C2H2 Zn finger	330..350	CDD:275368	11/19 (58%)
		zf-H2C2_2	342..366	CDD:290200	13/23 (57%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	73/190 (38%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	8/19 (42%)
znf1068	NP_001104669.1	C2H2 Zn finger	83..103	CDD:275368	5/19 (26%)
		zf-H2C2_2	95..118	CDD:290200	8/26 (31%)
		COG5048	107..>411	CDD:227381	130/312 (42%)
		C2H2 Zn finger	111..131	CDD:275368	8/19 (42%)
		zf-H2C2_2	123..148	CDD:290200	12/24 (50%)
		C2H2 Zn finger	139..159	CDD:275368	9/19 (47%)
		zf-H2C2_2	151..176	CDD:290200	11/24 (46%)
		C2H2 Zn finger	167..187	CDD:275368	11/19 (58%)
		zf-H2C2_2	179..202	CDD:290200	13/22 (59%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		zf-H2C2_2	207..230	CDD:290200	11/22 (50%)
		C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		zf-H2C2_2	235..260	CDD:290200	12/24 (50%)
		C2H2 Zn finger	251..271	CDD:275368	10/19 (53%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..316	CDD:290200	16/24 (67%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		zf-H2C2_2	319..344	CDD:290200	9/26 (35%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17305
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840