DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp386

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001004066.1	Gene:	Zfp386 / 56220	MGIID:	1930708	Length:	626	Species:	Mus musculus

Alignment Length:	629	Identity:	172/629 - (27%)
Similarity:	264/629 - (41%)	Gaps:	170/629 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EISDPPIWEMLNSILPE----ICRVKRDEMPQKICPTC---------LVAAQNAFH-----FRHK 84
            |..|||...:...::.|    :..|..|.:|.::...|         :.|...|||     ..|.
Mouse    21 ECLDPPQQRLYRDVMVENYRNLVSVGEDSIPAELPTHCHHFMPFLSKMSAIACAFHKQYKPLSHH 85

  Fly    85 CEQSFQFFSQLLQ---LDKSNSNLSRSH------CRRGTMNPLIPFEIVGC----EDPLDTNVTK 136
            |.|:|. ..|:|:   .:.:|.:.|..|      |.....|     :...|    :..|.|:.||
Mouse    86 CTQNFS-PEQILKYSFTEVTNGSYSLQHLYLREDCANVGGN-----KAAACHGRHKQCLITSNTK 144

  Fly   137 LDAN--------RPDVKTD-IDEPTDGKATNGQESEPLQEVFEITMNDIKTEDEVSIQETFEDAF 192
            .:.|        :|..:|| .|||.      ....:..||:|         :.:::::|::||..
Mouse   145 DNRNQEQKTALKKPHARTDTFDEPC------VYNCKYPQEIF---------QHDLTLKESWEDLI 194

  Fly   193 DE---------------------------------------------ENDNNN------TD---- 202
            |.                                             :..|.|      ||
Mouse   195 DRLIFHSSNFIDKELRNRGPISKSDQVESSYPGRAILFSQQIPVSCGQKHNTNDCGLPATDPLLH 259

  Fly   203 SEREDSDQW-------------TVGS--TEDQDEPWIPGGGGRQTV---------GGNNQSLL-- 241
            |:..|:|.|             :.||  ....|...:...|.|..|         ..|:|..|
Mouse   260 SQNLDTDIWETPYMYKEISKGFSSGSLLNSCNDVVILEKSGQRDKVQNDFDHCLSPNNHQCNLPK 324

  Fly   242 ----C----TEC-----------------GVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGF 281
                |    |:|                 .:...|......:|.:.|.| .::|.:.|:.||:.|
Mouse   325 KLFNCDNFFTQCSKLTIQQCNYIQDNHYKSIDCDTMFNKTLNVTRRKIQ-HSKKSYKCNECGKAF 388

  Fly   282 RTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAH 346
            :..:....|...||||:|:||.||.|::|...:||.|...|..||.::|.:|.::|.....|..|
Mouse   389 KYCSSYRKHSIIHTGEKPYKCKLCGKSFTQCASLKKHQRIHTGEKPYRCEECGRSFNHYSILGQH 453

  Fly   347 IQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQ 411
            .:.||||:||||..|.::|.:.|.|:.|..:|..|:|::|..|||.|.||..|..|.|:|.|::.
Mouse   454 QRIHTGEKPYKCKQCGKSFTQCSSLQKHQVIHTGEKPYRCAECGKSFTQNSTLSQHQRIHTGEKP 518

  Fly   412 FKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKG 476
            :||.:|.|:|.:.|::.||||.|:|.||:|||.||:||:.......|.|||||||||||..|.|.
Mouse   519 YKCEECGKAFTQCSSLRKHQRIHTGEKPYKCEVCGRAFNCRSSFTKHKRIHTGEKPYKCKDCDKA 583

  Fly   477 FSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTH 520
            |....:|::|...|  ..::|:||::|.|::....:||.||:.|
Mouse   584 FIHCTNLIQHQRIH--TGEKPYKCNECGKSFSQCSNLRKHERIH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	17/74 (23%)
		C2H2 Zn finger	242..262	CDD:275368	5/40 (13%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		COG5048	<395..583	CDD:227381	56/126 (44%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	15/24 (63%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	14/23 (61%)
		C2H2 Zn finger	470..486	CDD:275368	5/15 (33%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
Zfp386	NP_001004066.1	KRAB	6..>46	CDD:214630	5/24 (21%)
		KRAB	6..45	CDD:279668	5/23 (22%)
		C2H2 Zn finger	356..373	CDD:275368	3/16 (19%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	393..418	CDD:290200	11/24 (46%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	421..446	CDD:290200	9/24 (38%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		zf-H2C2_2	452..474	CDD:290200	11/21 (52%)
		COG5048	<461..621	CDD:227381	70/161 (43%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		zf-H2C2_2	477..502	CDD:290200	10/24 (42%)
		C2H2 Zn finger	493..513	CDD:275368	10/19 (53%)
		zf-H2C2_2	506..530	CDD:290200	10/23 (43%)
		C2H2 Zn finger	521..541	CDD:275368	9/19 (47%)
		zf-H2C2_2	533..558	CDD:290200	15/24 (63%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		zf-H2C2_2	561..584	CDD:290200	14/22 (64%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		zf-H2C2_2	589..614	CDD:290200	8/26 (31%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930