DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and znf989

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001018578.1	Gene:	znf989 / 553777	ZFINID:	ZDB-GENE-050522-337	Length:	381	Species:	Danio rerio

Alignment Length:	424	Identity:	148/424 - (34%)
Similarity:	208/424 - (49%)	Gaps:	55/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESEPL--QEVFEITMNDIKTEDEVSI-QETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDE 221
            :|||.|  ::.|.:...|.:.:.|:.: :|.|:|.    |:...:..||.........||..:..
Zfish     6 EESEDLKIEDTFSVKHEDPEEQTELMVLKEEFQDL----NEMEESQCERHQDLTTDEKSTPKKSL 66

  Fly   222 PWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQ 286
            |       .:.|..||  ..|..||..:|.:.:|..|:..|  .||  |...||.||:.|...::
Zfish    67 P-------HKRVQKNN--FTCCVCGKCFSQRHSLKVHMRIH--TGD--KLFTCDQCGKSFTQKSK 118

  Fly   287 LTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHT 351
            :..|.|.||.||.:.||.|.|.:.....||.||..|..||...|.||.|.|.....|::|...|:
Zfish   119 IDVHMRVHTSERHYSCPQCAKGFRQKQHLKLHMRIHSGEKPFPCNQCGKRFNQLQALQSHFTIHS 183

  Fly   352 GERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPD 416
            |||||.|..|.::|.:...|:.|.::|..|:||.|..||.||.|.:.|..|:|:|.|::.|.||.
Zfish   184 GERPYACTQCEKSFRQRPSLEKHLKVHSREKPFTCSQCGNGFTQKERLQNHMRIHTGEKPFACPH 248

  Fly   417 CDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQ 481
            |:|:|..:||:..|.|||||.|||.|..||::|...:.|..|:|.||||||:.||||||.||...
Zfish   249 CEKTFAHRSNLYFHVRTHSGEKPFVCTHCGKSFRCKNSLVGHMRTHTGEKPFACDQCGKSFSREF 313

  Fly   482 SLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLD 546
            :|..|...|  ..::|:.|.||.|::..:.||..||..|.     |.:: |.||...|
Zfish   314 NLKCHMSNH--TGEKPYTCGQCGKSFVRKDSLNRHELIHS-----KGIN-CHHCGKSF------- 363

  Fly   547 KHITSHKIRPHPCPQCPEGFFSQKSLKKHLRLHN 580
                :||                .|.|.|:|||:
Zfish   364 ----NHK----------------TSFKSHMRLHS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	70/186 (38%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	14/24 (58%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	9/15 (60%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	4/19 (21%)
		C2H2 Zn finger	559..579	CDD:275370	4/19 (21%)
znf989	NP_001018578.1	C2H2 Zn finger	78..98	CDD:275368	6/19 (32%)
		zf-H2C2_2	90..115	CDD:290200	11/28 (39%)
		C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		C2H2 Zn finger	134..154	CDD:275368	8/19 (42%)
		zf-H2C2_2	146..171	CDD:290200	12/24 (50%)
		COG5048	<149..377	CDD:227381	101/262 (39%)
		C2H2 Zn finger	162..182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	190..210	CDD:275368	5/19 (26%)
		C2H2 Zn finger	218..238	CDD:275368	9/19 (47%)
		zf-H2C2_2	231..255	CDD:290200	11/23 (48%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		zf-H2C2_2	258..283	CDD:290200	14/24 (58%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	290..311	CDD:290200	15/20 (75%)
		C2H2 Zn finger	302..322	CDD:275368	10/19 (53%)
		zf-H2C2_2	314..339	CDD:290200	8/26 (31%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		C2H2 Zn finger	356..376	CDD:275368	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900