DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and zgc:113209

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001017546.1	Gene:	zgc:113209 / 548342	ZFINID:	ZDB-GENE-050410-8	Length:	528	Species:	Danio rerio

Alignment Length:	493	Identity:	147/493 - (29%)
Similarity:	232/493 - (47%)	Gaps:	92/493 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 IKTEDE-VSIQET--FEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGG----GRQTV 233
            ||.|.| :.|:||  :||| :::.|..:.:.:.|:.|.  |...:|.:|......|    |.||.
Zfish     4 IKEESEDLKIEETVRYEDA-EQQTDQMHLNEDIEELDD--VKEEKDLEEEQHSTSGKTPLGSQTE 65

  Fly   234 GGNNQS---------LLCTECGVSYSTQKALARHVAKH---------------KEQG-------- 266
            ..:.::         .:|.:||..:||.:.|..|:..|               .|:|
Zfish    66 STSQKTAQSGRAASCFICQQCGKGFSTNRKLNIHMRIHTGEKPFACPQCGKCFAEKGNLKSHMIT 130

  Fly   267 --DT-QKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGH 328
              || ::||.|:.||:.|.....|..|...||||:|.:|..|.|:::....|..||..|..||.:
Zfish   131 HEDTGERPHTCELCGKSFSRKRYLDVHMMIHTGEKPCRCEQCGKSFSIKKYLDVHMRIHSGEKPY 195

  Fly   329 KCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGF 393
            .||||:.:|..:.:|:.|::.||||:|:.||.|.:.|.:.:.|::|.|:|..|:|::||.||..|
Zfish   196 TCPQCEISFIHKNSLKRHMRIHTGEKPFACPQCGKQFTRTTNLEVHMRVHTGEKPYECEQCGDSF 260

  Fly   394 VQNQHLITHLRVHNGDRQFK----------------CPDCDKSFFEKSNMMKHQRTHSGIKPFKC 442
            ..::.|..|::.|..::.:.                ||.|.|.|..||.:..|.|.|:|.||:.|
Zfish   261 TTHKKLEVHMKTHTREKPYDQREETYDSHTSKKPYICPQCGKHFKHKSTLTLHMRLHTGEKPYTC 325

  Fly   443 EECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWH----------------- 490
            |:||::||.....:||.|||...|||.|.||||.|:..:|...|...|
Zfish   326 EQCGKSFSRKDCFESHRRIHMDVKPYICPQCGKDFTLIRSFNLHMRTHTRDKLFTCGQCGKSFVQ 390

  Fly   491 ---------VDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLD 546
                     :...:|||.|.||.|.:.::.:|:.|.|.|..    ::.:.|..|...|.....|.
Zfish   391 KCNLDSHMIIHTEERPFVCCQCGKCFRSKSNLKSHMKVHSK----ESRYMCRQCGTSFPDGGQLR 451

  Fly   547 KHITSH-KIRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583
            .|:.:| ..:|:.|.:|......:.|||.|:|:|:.:|
Zfish   452 DHVKTHIGEKPYMCLECGRSCTKKTSLKIHMRIHSGEK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	65/230 (28%)
		zf-C2H2	412..434	CDD:278523	9/37 (24%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	13/23 (57%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
zgc:113209	NP_001017546.1	COG5048	53..446	CDD:227381	118/396 (30%)
		C2H2 Zn finger	83..103	CDD:275368	7/19 (37%)
		zf-H2C2_2	96..119	CDD:290200	3/22 (14%)
		C2H2 Zn finger	111..131	CDD:275368	2/19 (11%)
		C2H2 Zn finger	141..161	CDD:275368	6/19 (32%)
		C2H2 Zn finger	169..189	CDD:275368	6/19 (32%)
		zf-H2C2_2	181..204	CDD:290200	10/22 (45%)
		C2H2 Zn finger	197..217	CDD:275368	7/19 (37%)
		zf-H2C2_2	209..234	CDD:290200	11/24 (46%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		zf-H2C2_2	237..262	CDD:290200	11/24 (46%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		C2H2 Zn finger	297..317	CDD:275368	9/19 (47%)
		zf-H2C2_2	310..334	CDD:290200	11/23 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		C2H2 Zn finger	381..401	CDD:275368	0/19 (0%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:290200	7/13 (54%)
		C2H2 Zn finger	493..513	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000