DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and zgc:113343

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001014384.1	Gene:	zgc:113343 / 541549	ZFINID:	ZDB-GENE-050327-90	Length:	356	Species:	Danio rerio

Alignment Length:	411	Identity:	138/411 - (33%)
Similarity:	198/411 - (48%)	Gaps:	62/411 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 IKTEDE---VSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNN 237
            ::||:|   :..:|| |:..|.  |.|...|:.||:.:              |...||..|.|
Zfish     1 METEEEPCRIKEEET-EEQIDA--DENAVSSQTEDTSR--------------PKQAGRTAVEG-- 46

  Fly   238 QSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKC 302
             |.:|:|||.||.::.:|.||...|..||    ...|..||:.|....||..|.|.||||||:.|
Zfish    47 -SFICSECGKSYKSKDSLYRHTRFHSGQG----LFTCTQCGKDFVQKGQLDKHMRIHTGERPYAC 106

  Fly   303 PLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAK 367
            ..|.|:|....|||.|..||..||...|.||.|:|..|..|:.|...|...:|:.|..|.:.|..
Zfish   107 SQCGKSYNDAATLKMHTKTHSGEKPFTCIQCGKSFIYRKTLKDHQLSHNAVKPFSCDQCSKAFTL 171

  Fly   368 NSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQR 432
            ...|:.|..:|...:|:.| .|||.:.....|..|.|:|.|::.::|..|.|:|...:::..|||
Zfish   172 EKYLRQHLHVHAAVKPYVC-FCGKSYTTMNMLNEHQRIHTGEKLYQCSHCAKNFTYSNSLKVHQR 235

  Fly   433 THSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRP 497
            .|:|.||::|..||::|:....||:|.|||||.|||.|..|||.||.:.||..|...|  ..::|
Zfish   236 IHTGEKPYRCSSCGKSFTQLASLKAHQRIHTGVKPYVCSDCGKSFSTSSSLTAHRRIH--TGEKP 298

  Fly   498 FKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHKIRPHPCPQC 562
            ::||.|.|:::....|:.|:|.|                             |..|  ||.|..|
Zfish   299 YQCSHCGKSFNRTGGLKDHQKVH-----------------------------TGEK--PHQCSSC 332

  Fly   563 PEGFFSQKSLKKHL-RLHNLK 582
            .:.|....:|:.|: ::|:.|
Zfish   333 GKSFTQMSNLRVHIEKIHSPK 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	9/19 (47%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	342..366	CDD:290200	6/23 (26%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	61/189 (32%)
		zf-C2H2	412..434	CDD:278523	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	8/15 (53%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	1/19 (5%)
		C2H2 Zn finger	559..579	CDD:275370	5/20 (25%)
zgc:113343	NP_001014384.1	COG5048	24..>341	CDD:227381	126/371 (34%)
		C2H2 Zn finger	50..70	CDD:275368	9/19 (47%)
		C2H2 Zn finger	78..98	CDD:275368	8/19 (42%)
		zf-H2C2_2	91..114	CDD:290200	12/22 (55%)
		C2H2 Zn finger	106..126	CDD:275368	8/19 (42%)
		zf-H2C2_2	119..143	CDD:290200	12/23 (52%)
		C2H2 Zn finger	134..154	CDD:275368	8/19 (42%)
		C2H2 Zn finger	162..182	CDD:275368	5/19 (26%)
		C2H2 Zn finger	192..209	CDD:275368	6/16 (38%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		zf-H2C2_2	229..254	CDD:290200	11/24 (46%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		zf-H2C2_2	257..282	CDD:290200	16/24 (67%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	285..310	CDD:290200	9/26 (35%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..338	CDD:290200	11/54 (20%)
		C2H2 Zn finger	329..350	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910