DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and zgc:113119

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001014315.2	Gene:	zgc:113119 / 541480	ZFINID:	ZDB-GENE-050327-3	Length:	420	Species:	Danio rerio

Alignment Length:	428	Identity:	138/428 - (32%)
Similarity:	203/428 - (47%)	Gaps:	54/428 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESEPLQ--EVFEITMNDIKTE-DEVSIQETF--------EDAFDEENDNNNTDSEREDSDQWTV 213
            |||:.::  |||.:...|.:.: |.:.:::.|        |:|..||: .:.|.:|:..:...|.
Zfish     6 QESDDIRIAEVFTLKQEDPEEQTDLLPLRKEFQGLDNVKEEEALVEEH-QDITPAEKRITCSETE 69

  Fly   214 GSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQ----------GDT 268
            .:|:...|.           .|:..|..|.:||..::.|..|..|:..|..:          |.|
Zfish    70 NTTQKASEK-----------TGSRSSFTCEQCGRDFAKQGTLNNHMRIHTGEKSFTCQQCGKGFT 123

  Fly   269 QKPHL--------------CDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHM 319
            ||..|              |..||..|.....||.|.|.||||:.|.|..|.|.:.....|:.|:
Zfish   124 QKRTLRNHIRFHIEAESLSCQQCGESFTQKQDLTDHMRVHTGEKSFVCDQCGKVFLRKDGLEKHL 188

  Fly   320 HTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPF 384
            ..|.:||.|.|| |.|:|..:..|..|.:.||||:|:.|..|.:.|:....|..|.|.|..|.|:
Zfish   189 KNHHKEKPHVCP-CGKSFTDKTKLEEHTKTHTGEKPHTCDKCDECFSGKYDLIRHMRFHSAETPY 252

  Fly   385 KCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAF 449
            .|:.|||.|...:.|:||:::|..||.|.|..|.|.|:.|.|..:|.|.|:|.||:.|.|||::|
Zfish   253 ICQQCGKSFALKRVLMTHVKIHTRDRPFLCKQCGKCFYRKDNFNRHVRVHTGEKPYACSECGKSF 317

  Fly   450 SHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLR 514
            |.......|.|.|:|.|.:.|:|||:||:....|.:|  ..|...::|:.|.||.|.|..:....
Zfish   318 SERFQFNEHSRTHSGVKRFSCEQCGRGFNRKTELKRH--MRVHTGEKPYMCPQCGKTYAFKTGFD 380

  Fly   515 GHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSH 552
            .| ..|.|.:.|   :.||.|..||::|:..|.|:..|
Zfish   381 IH-MLHHNAEMP---YICPQCGERFSVKQRFDVHMKIH 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	58/158 (37%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	10/23 (43%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275370
zgc:113119	NP_001014315.2	C2H2 Zn finger	87..107	CDD:275368	6/19 (32%)
		COG5048	<111..262	CDD:227381	52/151 (34%)
		C2H2 Zn finger	115..135	CDD:275368	5/19 (26%)
		C2H2 Zn finger	143..163	CDD:275368	8/19 (42%)
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		C2H2 Zn finger	199..218	CDD:275368	7/19 (37%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		C2H2 Zn finger	254..274	CDD:275368	8/19 (42%)
		COG5048	277..>417	CDD:227381	54/144 (38%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)
		C2H2 Zn finger	338..358	CDD:275368	8/21 (38%)
		C2H2 Zn finger	366..383	CDD:275368	6/17 (35%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000