DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and Zfp879

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001128072.1	Gene:	Zfp879 / 497896	RGDID:	1563273	Length:	555	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	128/340 - (37%)
Similarity:	188/340 - (55%)	Gaps:	11/340 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306
            |.||..::|...:|.:|:..|    ..:||::|..||:.|.....|..|:|.||||||::|..|.
  Rat   226 CKECRKAFSQSSSLTQHLRVH----TGEKPYVCSECGKAFSFTTSLIGHQRMHTGERPYRCKECG 286

  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGL 371
            |.:....:|.:|...|..||.:.|..|.:.|....:|..|.:.||||:||:|..|.:.|...|.|
  Rat   287 KTFKGSSSLNNHQRIHTGEKPYTCSVCGRAFSQCSSLIQHQRIHTGEKPYECSQCGKAFTSISRL 351

  Fly   372 KLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSG 436
            ..|.|:|..|:||.|.:|||.|..:..||.|.|:|.|::.:.|.:|.|:|.:.|.:::|||.|:|
  Rat   352 SRHHRIHTGEKPFHCNVCGKVFSYHSALIIHQRIHTGEKPYACKECGKAFSQSSALIQHQRIHTG 416

  Fly   437 IKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCS 501
            .||:||:|||:|||....|..|.|||||||||.|.:|||.||::.::..|...|  ..::|:|||
  Rat   417 EKPYKCDECGKAFSWISRLNIHHRIHTGEKPYHCKECGKAFSSHSAVNTHRKIH--TGEKPYKCS 479

  Fly   502 QCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEG 565
            .|.||::...:|..|::.|.. ::|   ..|..|...|....:|..|...|. .:|:.|..|.:.
  Rat   480 DCEKAFNQSSALIQHQRIHTG-EKP---FNCKVCGKAFRQSSSLMTHTRIHTGEKPYKCKTCGKA 540

  Fly   566 FFSQKSLKKHLRLHN 580
            |....||..|.:.||
  Rat   541 FSQSSSLANHQKTHN 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	71/187 (38%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	14/24 (58%)
		C2H2 Zn finger	442..462	CDD:275368	10/19 (53%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	6/19 (32%)
Zfp879	NP_001128072.1	KRAB	14..72	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	194..554	CDD:227381	126/337 (37%)
		C2H2 Zn finger	198..218	CDD:275368
		zf-H2C2_2	210..235	CDD:290200	3/8 (38%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..262	CDD:290200	8/27 (30%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..290	CDD:290200	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		zf-H2C2_2	294..319	CDD:290200	8/24 (33%)
		C2H2 Zn finger	310..330	CDD:275368	5/19 (26%)
		zf-H2C2_2	322..347	CDD:290200	11/24 (46%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		zf-H2C2_2	351..375	CDD:290200	12/23 (52%)
		C2H2 Zn finger	366..386	CDD:275368	9/19 (47%)
		zf-H2C2_2	378..403	CDD:290200	10/24 (42%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		zf-H2C2_2	406..430	CDD:290200	13/23 (57%)
		C2H2 Zn finger	422..442	CDD:275368	10/19 (53%)
		zf-H2C2_2	435..459	CDD:290200	16/23 (70%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	9/26 (35%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	7/28 (25%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
		zf-H2C2_2	518..543	CDD:290200	7/24 (29%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000