DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and im:7141269

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_002661922.1	Gene:	im:7141269 / 492560	ZFINID:	ZDB-GENE-041111-134	Length:	368	Species:	Danio rerio

Alignment Length:	381	Identity:	128/381 - (33%)
Similarity:	196/381 - (51%)	Gaps:	25/381 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 MNDIKTEDE-VSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGN 236
            |..||.|.| |.|.|.....:::..:..:....:|:..:    ..|.:::|..           .
Zfish     3 MEFIKEESEDVKIIEMVTIKYEDPEEQADLVEPKEEPQE----LIEMEEKPQC-----------E 52

  Fly   237 NQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFK 301
            .|.:..||...:.:||  .:...:|..::.......:|..||:.|.....|..|...|.||:|:.
Zfish    53 TQHVSATEEPHTEATQ--TSTRTSKSPQKSKPSSLFICCQCGKSFTRKQSLEGHMNLHNGEKPYS 115

  Fly   302 CPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFA 366
            |..|.|::...|.|:.||..|..||.:.|.||.|:|......:.|::.||||:||.|..|.:.|:
Zfish   116 CQQCGKSFRQKPNLRVHMRVHTGEKPYTCKQCGKSFSLVQGFKIHMRSHTGEKPYVCQQCGKGFS 180

  Fly   367 KNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQ 431
            :.|....|:|:|..|:|:.|:||||.|...|||..|:.:|:.::.|:|..|.|:||.|.::.||.
Zfish   181 QISSFNSHTRIHTREKPYSCQLCGKDFSIKQHLNDHMIIHSAEKAFECQQCGKTFFLKRHLKKHI 245

  Fly   432 RTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDR 496
            |.|||.|.|.|:.||.:|:..:.||.|:|||:|||||.|.||||.|:.|.||..|...|   .:|
Zfish   246 RVHSGEKNFTCQLCGNSFTQMYSLKRHMRIHSGEKPYSCQQCGKRFTQNNSLDIHVRTH---TER 307

  Fly   497 PFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSH 552
            .|.|.:|.::::.:..|..|.|||   .|.|.. .|..|:..|:.|..|::|:.:|
Zfish   308 SFTCQECGESFNLKSDLNNHVKTH---GEEKAF-PCGQCEKSFSRKDNLNRHMRAH 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		COG5048	<395..583	CDD:227381	64/158 (41%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	16/23 (70%)
		C2H2 Zn finger	470..486	CDD:275368	9/15 (60%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370
im:7141269	XP_002661922.1	COG5048	69..>362	CDD:227381	112/298 (38%)
		C2H2 Zn finger	88..108	CDD:275368	6/19 (32%)
		C2H2 Zn finger	116..136	CDD:275368	7/19 (37%)
		C2H2 Zn finger	144..164	CDD:275368	6/19 (32%)
		C2H2 Zn finger	172..192	CDD:275368	6/19 (32%)
		C2H2 Zn finger	200..220	CDD:275368	10/19 (53%)
		C2H2 Zn finger	228..248	CDD:275368	9/19 (47%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	10/19 (53%)
		C2H2 Zn finger	311..331	CDD:275368	5/19 (26%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900