DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and ZNF716

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001152751.1	Gene:	ZNF716 / 441234	HGNCID:	32458	Length:	495	Species:	Homo sapiens

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	233/510 - (45%)	Gaps:	76/510 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LDKSNSNLSRSHCRRGTMNPLIPFEIVGCEDPLDTNVTKLDANRPDVKTDIDEPTDGKATNGQES 162
            ||.:..||.|........| |:...|.              .::||:.|.::          |..
Human    33 LDHAQQNLYRDVMLENYRN-LVSLGIA--------------VSKPDLITCLE----------QNK 72

  Fly   163 EPLQEVFEITMNDIKTEDEVSIQETFEDAFDEENDNNNTDS---------EREDSDQ----WTVG 214
            ||.    .|..|::..:..|:.....:|...|:...::...         .:||...    .:||
Human    73 EPQ----NIKRNEMVAKHPVTCSHFTQDLQSEQGIKDSLQKVILRRYGKCGQEDLQVKKCCKSVG 133

  Fly   215 STEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALA---------RHVAKHKEQGDTQK 270
            ..|...       ||...|   ||.|..|: ..::.|.|.:.         ||..:|     |.|
Human   134 ECEVHK-------GGYNYV---NQCLSATQ-NKTFQTHKCVKVFGKFSNSNRHKTRH-----TGK 182

  Fly   271 PHL-CDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCD 334
            .|. |...|:.|...::|..|:..||.|:.:||..|.|::....||..|...|..||.::|.:|.
Human   183 KHFKCKNDGKSFCMLSRLNQHQIIHTREKSYKCEECGKSFNCSSTLTRHKRIHTGEKPYRCEECG 247

  Fly   335 KTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHL 399
            |.|....:|..|.:.||||:||.|.:..:.|:: |.|..:.|:|..|:|:.||.|||.|.::..|
Human   248 KAFSWSASLTKHKRIHTGEKPYTCEERGKVFSR-STLTNYKRIHTGEKPYTCEECGKAFSRSSTL 311

  Fly   400 ITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTG 464
            ..|.|:|.|:|.:||.:|.|:|...|.:.||:..|:|.|.:.|||||:||:.:..|.:|.|||||
Human   312 TNHKRIHTGERPYKCEECGKAFSLSSTLKKHKIVHTGEKLYTCEECGKAFTFSSTLNTHKRIHTG 376

  Fly   465 EKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTL 529
            ||||.|::|||.||...:...|...|  ..::|:||.:|.||::...:|:.|:..|..    :.|
Human   377 EKPYTCEECGKAFSLPSTFTYHKRTH--TGEKPYKCEECGKAFNCSSTLKKHKIIHTG----EKL 435

  Fly   530 HQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583
            ::|..|...|....||:.|...|. .:|:.|.:|.:.|....||..|..:|..:|
Human   436 YKCKECGKAFTFSSTLNTHKRIHTGEKPYKCEECDQTFKWHSSLANHKNMHTGEK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	5/28 (18%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	68/188 (36%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	10/19 (53%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	6/19 (32%)
ZNF716	NP_001152751.1	KRAB	16..76	CDD:214630	14/71 (20%)
		KRAB	16..55	CDD:279668	7/22 (32%)
		C2H2 Zn finger	160..179	CDD:275368	3/18 (17%)
		C2H2 Zn finger	187..207	CDD:275368	5/19 (26%)
		COG5048	211..>494	CDD:227381	105/287 (37%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		zf-H2C2_2	228..251	CDD:290200	8/22 (36%)
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..307	CDD:290200	11/23 (48%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		zf-H2C2_2	311..334	CDD:290200	10/22 (45%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		CpXC	353..>398	CDD:291051	24/44 (55%)
		C2H2 Zn finger	354..374	CDD:275368	10/19 (53%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..419	CDD:290200	8/22 (36%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..446	CDD:290200	6/26 (23%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		zf-H2C2_2	451..474	CDD:290200	6/22 (27%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950