DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp141

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001296317.1	Gene:	Zfp141 / 434178	MGIID:	3584269	Length:	685	Species:	Mus musculus

Alignment Length:	515	Identity:	165/515 - (32%)
Similarity:	250/515 - (48%)	Gaps:	73/515 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIVGCEDPLDTNVTKLDANR------- 141
            :|.|     |.|.|.|.|...||.|..:....|     |...|     :..|::.|.|
Mouse   226 QCTQ-----SPLYQQDYSQEKLSTSSQQYKIAN-----ECSNC-----SQCTEIKARREFNRQRY 275

  Fly   142 -PDVKTDIDEPT-DGKATNGQESEPL-----QEVFEITMNDIKTEDEVSIQETFEDAFDEENDNN 199
             ...|..::.|: |....|..:.:|.     .:.|...:|                  ..:||::
Mouse   276 DKYSKVSVESPSIDRDKVNDIQRKPCLFMGSDKSFNFYLN------------------MTQNDSS 322

  Fly   200 NTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKE 264
            :|..:.:...::.:..|........|....:|..   .:|..|:......|..|.|        :
Mouse   323 HTREKPQKYKEYRLEITSPSKLVGHPRSFVQQKY---RKSGKCSRSSSDLSRLKML--------Q 376

  Fly   265 QGDTQKPHLCDFCGRGFRTNAQLTTHRRR---HTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEK 326
            .|.|  |.....||:.|   :|.:.:|..   ||||:|:||.:|.:::|.|..|::|...|..||
Mouse   377 PGGT--PCKSTECGKSF---SQFSGYRENGTIHTGEKPYKCKICKRSFTTGSYLQAHQRIHTGEK 436

  Fly   327 GHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGK 391
            .:||.:|.|:|....:||.|.:.||||:||||.||.::||:.|.||.|.|:|..|:|:||:.|||
Mouse   437 PYKCKECGKSFTHGYSLRIHHRFHTGEKPYKCKDCGRSFAEGSSLKSHHRIHTGEKPYKCKECGK 501

  Fly   392 GFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLK 456
            .|.:..:..||.|:|.|||.:||.||.|||.....:.||.:||:|.|.:||||||:||:....||
Mouse   502 SFAKQSNFETHSRIHTGDRPYKCTDCGKSFTRSFCLRKHHKTHTGEKAYKCEECGKAFTQRSTLK 566

  Fly   457 SHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHK 521
            :|.|||||||||||::|||.|:...:|..|...|  ..::|:||.:|.|::....:|:.|.:.|.
Mouse   567 THYRIHTGEKPYKCNECGKSFTEGSTLKTHLKIH--TGEKPYKCKECGKSFAEASTLKTHHRIHT 629

  Fly   522 NPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFFSQKSLKKHLRLHN 580
            . ::|   ::|..|...|.....|..|...|. .:|:.|.:|.:.|....||:||.|:|:
Mouse   630 G-EKP---YKCTDCGKSFTQSSHLQSHCRIHTGEKPYKCKECGKSFAKDSSLQKHHRIHS 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	3/10 (30%)
		C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	274..294	CDD:275368	5/22 (23%)
		zf-H2C2_2	287..311	CDD:290200	9/26 (35%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	13/23 (57%)
		C2H2 Zn finger	358..378	CDD:275368	10/19 (53%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	74/187 (40%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	14/24 (58%)
		C2H2 Zn finger	442..462	CDD:275368	11/19 (58%)
		zf-H2C2_2	454..478	CDD:290200	17/23 (74%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	8/19 (42%)
Zfp141	NP_001296317.1	KRAB	18..78	CDD:214630
		C2H2 Zn finger	385..404	CDD:275368	5/21 (24%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		zf-H2C2_2	424..449	CDD:372612	10/24 (42%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		COG5048	<445..685	CDD:227381	104/245 (42%)
		C2H2 Zn finger	468..488	CDD:275368	10/19 (53%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	552..572	CDD:275368	11/19 (58%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930