DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and trem

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_650861.1	Gene:	trem / 42392	FlyBaseID:	FBgn0038767	Length:	439	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	132/549 - (24%)
Similarity:	205/549 - (37%)	Gaps:	181/549 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CRAC----AEHSSILVDLFSKEISDPPIWEMLNSILPEICR---VKRDE-MPQKICPTCLVAAQN 77
            ||.|    :|...:|.|:|| |.:...:.:||:     ||.   |..|: .|.|:|..|:...:.
  Fly    12 CRVCLNNPSEGEELLHDIFS-ETASTRLDQMLH-----ICAGIPVSLDDNFPDKMCSKCVRCLRL 70

  Fly    78 AFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIVGCEDPL----DTNVTKLD 138
            .:.||..|::|.|....:|..:.||:|.:                  |..|.|    |.:|..:.
  Fly    71 CYKFRLTCQRSHQHIMDMLDREASNANAA------------------GEGDLLSIAEDLSVESVL 117

  Fly   139 ANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTED---------------EVSIQETF 188
            .:..|..:.:|   .|....|:|.:. .:|....:.|..|:|               |:...||:
  Fly   118 KSWEDYASQLD---GGMKVEGEEDQQ-HQVITYVVEDGDTDDTNMFDVHDPTQPVPNEIEEAETY 178

  Fly   189 EDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQK 253
            .: ::|.....|.:|.....::.:.|:....:||                            .::
  Fly   179 AE-YEEYELLTNENSPEIAQEKGSTGTDVATEEP----------------------------PEE 214

  Fly   254 ALARHVAKHKEQGDT--QKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLK 316
            .:|..:....|..|.  .||..||..||.                         |.||
  Fly   215 EIAEDILDSDEDYDPTHAKPEKCDRSGRK-------------------------PVAY------- 247

  Fly   317 SHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERP------YKCPDCPQTFAKNSGLKLHS 375
                       ||.....:||          ::..|.:|      |.|..|...:...:.|..|.
  Fly   248 -----------HKNSPKVETF----------KKKVGRKPRNKLSTYICDVCGNIYPTQARLTEHM 291

  Fly   376 RLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPF 440
            :.|...:|.:||:||:||||||.|:.|:..|.|:|.:||..|..:|.::|...||.|.|:..:|:
  Fly   292 KFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKHHRIHTKERPY 356

  Fly   441 KCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPK 505
            .|:.|.:.|:::.:||.|..|||||||:.||.|||||                          .|
  Fly   357 VCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGF--------------------------VK 395

  Fly   506 AYDTQQSLRGHEKTH------KNPDEPKT 528
            ||    .||.|.:||      :|..|..|
  Fly   396 AY----KLRLHRETHNRRITWRNDAEEST 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	24/81 (30%)
		C2H2 Zn finger	242..262	CDD:275368	1/19 (5%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		zf-H2C2_2	287..311	CDD:290200	3/23 (13%)
		C2H2 Zn finger	302..322	CDD:275368	3/19 (16%)
		C2H2 Zn finger	330..350	CDD:275368	2/19 (11%)
		zf-H2C2_2	342..366	CDD:290200	5/29 (17%)
		C2H2 Zn finger	358..378	CDD:275368	4/19 (21%)
		C2H2 Zn finger	386..406	CDD:275368	12/19 (63%)
		COG5048	<395..583	CDD:227381	49/140 (35%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	8/24 (33%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	16/23 (70%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
trem	NP_650861.1	zf-AD	11..87	CDD:214871	24/80 (30%)
		COG5048	<264..411	CDD:227381	61/176 (35%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	12/19 (63%)
		zf-H2C2_2	315..338	CDD:290200	8/22 (36%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	8/21 (38%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..394	CDD:290200	17/49 (35%)
		C2H2 Zn finger	386..406	CDD:275368	13/49 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930