DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and CG6654

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	164/625 - (26%)
Similarity:	248/625 - (39%)	Gaps:	116/625 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KNCRACAEHSSILVDLFSKEISDPPIWEMLNSILPEICRVK---RDEMPQKICPTCLVAAQNAFH 80
            |.|..|...:..|:.::     |......|..::.|..:.|   .|.:|:|:|.:||....|.:.
  Fly     5 KICLTCLSSTGPLLSIY-----DGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYT 64

  Fly    81 FRHKCEQSFQFFSQLLQ---LDKSNSNLSRSHCRRGTMNPLI---PFEIVGCEDPLDTN-VTKLD 138
            |:.|||.|.:...|||.   .::.:|.:|.| |...|.:..:   .:|...|...:.|: ||..|
  Fly    65 FKIKCENSSRTLRQLLPNALPEEPDSKVSIS-CPVATTDQAVQTTSWEPDRCTASVQTDAVTTTD 128

  Fly   139 AN------RPDVKTDIDEPTDGKATNGQ-ESEPLQEVFEITM---NDIKTEDEVSIQET--FEDA 191
            |.      :..:..|:|...:|:..:.: ..||:::...:.:   .::|.|.||...:|  ..:.
  Fly   129 AEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEG 193

  Fly   192 FDEENDN----------NNTDSERE------------------------DSDQWTVGSTED---- 218
            .|.|.:.          ...|:|.|                        |..|..|||.|:
  Fly   194 DDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEAREL 258

  Fly   219 --------------------QDEPWIPGGGG----RQTVGGNNQSLLCTECGVSYSTQKALARHV 259
                                ||.|..|....    :|...|..:.|.....|........
  Fly   259 EKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTT----- 318

  Fly   260 AKHKEQGDTQKPHL---CDFCGRGFRTNAQLTTHRRRHTG--ERPFKCPLCPKAYTHGPTLKSHM 319
                 .|....|.|   ||.|..||.....|..|||: .|  .|.:||..|.|.:.....|..|.
  Fly   319 -----SGAATTPELKYHCDRCNAGFAVEKSLMIHRRQ-KGCINRNYKCNECEKVFVSPDHLAEHQ 377

  Fly   320 HTHDEEKGHKCPQCDKTFYTRGNLRAH-IQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERP 383
            .:|.   .|.||:|.....::..|..| :|.|......:|..|.:.|...|.|:.|.|:|..|:|
  Fly   378 ASHG---AHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKP 439

  Fly   384 FKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQA 448
            |.|.:|||.|.||.:|..|...|:..:.|||..|..||..|:.:..|.|||:|.|||:||.|...
  Fly   440 FVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLAR 504

  Fly   449 FSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSL 513
            |:.:..|..|.|.||||:||.||.|...|:|...|..|...|  ..:||:.|..|.|.:..:...
  Fly   505 FTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTH--TGERPYVCPFCSKTFTQRGDC 567

  Fly   514 RGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK 553
            :.|::||:.    :.::.||.|:..|.....:..|:..|:
  Fly   568 QMHQRTHQG----ERIYICPVCNEEFKSMPEMRSHLAGHE 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	19/76 (25%)
		C2H2 Zn finger	242..262	CDD:275368	1/19 (5%)
		C2H2 Zn finger	274..294	CDD:275368	9/19 (47%)
		zf-H2C2_2	287..311	CDD:290200	10/25 (40%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	6/20 (30%)
		zf-H2C2_2	342..366	CDD:290200	6/24 (25%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	55/159 (35%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	4/19 (21%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	19/77 (25%)
		C2H2 Zn finger	331..354	CDD:275368	10/23 (43%)
		COG5048	<357..570	CDD:227381	77/217 (35%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	8/25 (32%)
		C2H2 Zn finger	554..574	CDD:275368	4/19 (21%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960