Protein Alignment Meics and topi

DIOPT Version :10

• Sequence 1: NP_524062.1
• Gene: Meics / 39539
• FlyBaseID: FBgn0025874
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 138/590 - (23%)
• Similarity: 196/590 - (33%)
• Gaps: 161/590 - (27%)

  Fly    49 NSILPEICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRG 113
            ||....:.|:|        ||||||.........|.||..        .::.:.....:.|....
  Fly   128 NSSASTVNRIK--------CPTCLVQFDAVAFQNHSCEAK--------PIEVAVPQQEKPHLVPT 176

  Fly   114 TMNPLIPFEIVGCEDPLDTNVTKL-----DANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITM 173
            ...|..|......|..:..|..:|     |..:.|:.|.| |.:...|..|..        |.||
  Fly   177 VSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGI-ESSRKNAAKGPN--------ECTM 232

  Fly   174 NDIKTEDEVSIQETFE-DAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNN 237
            .|.|......:....| .|.|                  .:.|...:....||..|....|
  Fly   233 CDRKFVHASGLVRHMEKHALD------------------LIPSQTSEQPHTIPAAGLHVVV---- 275

  Fly   238 QSLLCTECG-VSYSTQKALARHVAKHKEQGDT--QKPHL-------------------------- 273
               .|..|| :.|..|.|. ||...|..:..|  |.|..
  Fly   276 ---KCNSCGRIFYDPQVAF-RHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAF 336

  Fly   274 -------------------------CDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGP 313
                                     |:||...|...|:|..|...|..||.|:|..|
  Fly   337 ATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTAC-------- 393

  Fly   314 TLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLH---- 374
              ...|:|..|...|....|   .:.|..:|:  ...|..|.:.|..|...||....|:.|
  Fly   394 --DIQMNTAKEASIHFQTDC---IFMREAIRS--LNVTLSRYFVCNVCELKFANTDLLQEHRCTS 451

  Fly   375 ----SRLHKEERP--FKCELCGKGF---------VQNQHLITHLRV----HNGD---RQFKCPDC 417
                .||::..:.  ..|:.|...|         .:.:||....|.    :.|.   ||:.|..|
  Fly   452 FHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDIC 516

  Fly   418 DKSFFEKSNMMKHQRTHSGIKPFKCEE--CGQAFSHNHHLKSHLR-IHTGEKPYKCDQCGKGFSA 479
            .||:.:.|::.:|.|.|.|:|||.|:|  |.:.|:....|..|:| .||||:||.|..|||.|..
  Fly   517 GKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLT 581

  Fly   480 NQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKT 544
            .....:|.|.|  ..:|.::|.:|.|.:....:|:.|::.|.. ::|   :.|..|...|..:..
  Fly   582 GSVFYQHRLIH--RGERRYECEECGKRFYRADALKNHQRIHTG-EKP---YSCLFCTKTFRQRGD 640

  Fly   545 LDKHI 549
            .||||
  Fly   641 RDKHI 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	20..95	CDD:462262	13/45 (29%)
		C2H2 Zn finger	242..262	CDD:275368	8/20 (40%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		SFP1	<296..374	CDD:227516	19/77 (25%)
		COG5048	<299..486	CDD:227381	59/215 (27%)
		C2H2 Zn finger	302..322	CDD:275368	3/19 (16%)
		C2H2 Zn finger	330..350	CDD:275368	3/19 (16%)
		C2H2 Zn finger	358..378	CDD:275368	7/27 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/32 (19%)
		COG5048	<395..583	CDD:227381	54/165 (33%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	7/22 (32%)
		C2H2 Zn finger	470..486	CDD:275368	5/15 (33%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	7/18 (39%)
		C2H2 Zn finger	559..579	CDD:275370
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275370	8/20 (40%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	59/202 (29%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	612..637	CDD:463886	7/28 (25%)
		C2H2 Zn finger	628..646	CDD:275368	7/18 (39%)