DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Neu2

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_649316.1	Gene:	Neu2 / 40375	FlyBaseID:	FBgn0037085	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	122/462 - (26%)
Similarity:	182/462 - (39%)	Gaps:	117/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEI 123
            |.|.:...||.:||..|||||......|:|.||:..|..:.:..|....|
  Fly    29 KHDPLSNTICKSCLEDAQNAFDIIETYERSHQFYRFLKDVREEESENDGS--------------- 78

  Fly   124 VGCEDPLDTNVTKLDANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTEDEVSIQETF 188
             ||.:       :::|...|::...|:...|       :||     :|...|||.:::
  Fly    79 -GCSE-------EVEAAERDLQDGADDVDSG-------NEP-----DINECDIKAKEK------- 116

  Fly   189 EDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQK 253
                                                ||             ..|:.|..|:..:.
  Fly   117 ------------------------------------PG-------------FSCSHCPKSFQVKS 132

  Fly   254 ALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSH 318
            .|..|:..|    ..::|..|..|.:.|..::.|..|.|.|||||||:|..||:::|.|..||:|
  Fly   133 NLKVHMRSH----TGERPFTCSLCPKSFGYSSGLQNHMRTHTGERPFQCSHCPRSFTAGHHLKAH 193

  Fly   319 MHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERP 383
            :..|:.....:||.|.|.|.|...|:.|:..||.|..:||..|.::|.....|.:|.|:| :||.
  Fly   194 IQMHERRGSLRCPYCQKCFLTSLILKQHLATHTDETQFKCSQCSKSFQVEHELWMHMRVH-QERL 257

  Fly   384 FKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQA 448
            |.|..|.|.|..:.:|..||     .|..:|....|:...|:      ..||  |..||.:|.:.
  Fly   258 FTCGHCSKDFALHAYLKRHL-----SRNARCSQSSKASAHKT------LGHS--KALKCGKCPKT 309

  Fly   449 FSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSL 513
            |:....|.:||:.||..||.....|....|...        |.:...:|||||.||:.:..:.:|
  Fly   310 FTDRSALSTHLKSHTKNKPLLEGPCKSSGSKPA--------HSNAQRKPFKCSSCPRTFSRKSAL 366

  Fly   514 RGHEKTH 520
            ..|.:||
  Fly   367 LTHLQTH 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	15/35 (43%)
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	342..366	CDD:290200	8/23 (35%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	35/126 (28%)
		zf-C2H2	412..434	CDD:278523	3/21 (14%)
		C2H2 Zn finger	414..434	CDD:275368	3/19 (16%)
		zf-H2C2_2	426..451	CDD:290200	7/24 (29%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	8/23 (35%)
		C2H2 Zn finger	470..486	CDD:275368	2/15 (13%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
Neu2	NP_649316.1	zf-AD	1..63	CDD:285071	15/33 (45%)
		COG5048	<119..241	CDD:227381	43/125 (34%)
		C2H2 Zn finger	121..141	CDD:275368	5/19 (26%)
		zf-H2C2_2	133..158	CDD:290200	7/28 (25%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	162..185	CDD:290200	13/22 (59%)
		C2H2 Zn finger	177..197	CDD:275368	8/19 (42%)
		C2H2 Zn finger	205..225	CDD:275368	8/19 (42%)
		zf-C2H2_8	206..286	CDD:292531	30/85 (35%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..297	CDD:275368	11/47 (23%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	353..373	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3381
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.970