DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and MTF-1

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	139/539 - (25%)
Similarity:	209/539 - (38%)	Gaps:	189/539 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LVAAQNAFHFR----HKCEQSFQFFSQLLQL---------DKSNSNLSRSHCRRGTMNPLI---- 119
            |.|:|...|.:    ...:.:|....||..|         ..:..|||.||    :..|||
  Fly   132 LTASQTHGHSQVVVSAAADNAFSLADQLTPLPITVIPITYHHTTENLSSSH----SEVPLIASLS 192

  Fly   120 ------------------PFE---IVGCEDPLDTNVTKL----DANRPDVKTDIDEPTDGKATNG 159
                              .||   :|..:.|...:::.:    :|..|.:..|.|:.| |.:.:.
  Fly   193 DITAQVFNLDDICFTLEYQFENQRLVQVQPPTVVSLSMVSSPNEAANPPINCDNDQGT-GNSISR 256

  Fly   160 QESEPLQEVFEITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSE------------REDSDQWT 212
            ..:......|                 |.|.::.:|.|.|..|.:            .:|.|:..
  Fly   257 DSTSNSPAYF-----------------TIETSYVDEYDPNEPDEDEQLAHCIQPGVLHQDVDEEE 304

  Fly   213 VGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSY-STQKALARHVAKHKEQGDTQKPHLCDF 276
            |   |.|||               |..|:    .::| |:.:||:|
  Fly   305 V---ERQDE---------------NDQLM----ALAYESSDEALSR------------------- 328

  Fly   277 CGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRG 341
                :|.|.:                                             .|.:::.|.|
  Fly   329 ----YRCNYE---------------------------------------------NCYRSYSTIG 344

  Fly   342 NLRAHIQRHTGERPYKCPD--CPQTFAKNSGLKLHSRLHKEERPFKCEL--CGKGFVQNQHLITH 402
            |||.|::.|||:..:|||:  |.:.|..:..||:|.|:|.:.:|::||:  |.|.|.....|..|
  Fly   345 NLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAH 409

  Fly   403 LRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKC--EECGQAFSHNHHLKSHLRIHTGE 465
            ||:|||: .|.|..|.|.|...|::.||.|||:..:|:||  ::||:||:.:||||:|.|.||||
  Fly   410 LRLHNGE-TFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGE 473

  Fly   466 KPYKC--DQCGKGFSANQSLMKHTLWH---VDN---NDRPFKCSQ--C--PKAYDTQQSLRGHEK 518
            |||.|  |.|.|.||.:.||..|...|   :.|   ..||.|..|  |  .:..|.||..:..|:
  Fly   474 KPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQTKCSDQEQKDPQQEEQEEEE 538

  Fly   519 THKNPDEPK--TLHQCPHC 535
            ..|. |:|:  .|:...||
  Fly   539 FIKE-DQPEMTLLNPGSHC 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	5/26 (19%)
		C2H2 Zn finger	242..262	CDD:275368	5/20 (25%)
		C2H2 Zn finger	274..294	CDD:275368	2/19 (11%)
		zf-H2C2_2	287..311	CDD:290200	0/23 (0%)
		C2H2 Zn finger	302..322	CDD:275368	0/19 (0%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	11/25 (44%)
		C2H2 Zn finger	358..378	CDD:275368	8/21 (38%)
		C2H2 Zn finger	386..406	CDD:275368	9/21 (43%)
		COG5048	<395..583	CDD:227381	64/157 (41%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	12/26 (46%)
		C2H2 Zn finger	442..462	CDD:275368	11/21 (52%)
		zf-H2C2_2	454..478	CDD:290200	16/25 (64%)
		C2H2 Zn finger	470..486	CDD:275368	8/17 (47%)
		C2H2 Zn finger	500..520	CDD:275368	6/23 (26%)
		C2H2 Zn finger	532..552	CDD:275370	2/4 (50%)
		C2H2 Zn finger	559..579	CDD:275370
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	59/187 (32%)
		C2H2 Zn finger	331..353	CDD:275368	8/66 (12%)
		zf-H2C2_2	345..372	CDD:290200	12/26 (46%)
		C2H2 Zn finger	361..383	CDD:275368	8/21 (38%)
		zf-H2C2_2	375..402	CDD:290200	11/26 (42%)
		C2H2 Zn finger	391..413	CDD:275368	9/21 (43%)
		zf-C2H2	418..440	CDD:278523	9/21 (43%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..458	CDD:290200	11/25 (44%)
		COG5048	442..>519	CDD:227381	34/76 (45%)
		C2H2 Zn finger	448..470	CDD:275368	11/21 (52%)
		zf-H2C2_2	462..489	CDD:290200	17/26 (65%)
		C2H2 Zn finger	478..500	CDD:275368	9/21 (43%)
		DUF3682	862..>931	CDD:289231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100