DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and pita

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	632	Identity:	146/632 - (23%)
Similarity:	226/632 - (35%)	Gaps:	175/632 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CRACAEHSSILVDLFSKEISDPPIWEMLNSILPEICRVKR-------------------DEMPQK 66
            ||.|...                  :.|.||..|..|||.                   |.||..
  Fly    18 CRFCLTE------------------QKLASIFEENPRVKTTANLPLQIMAITAIEVYAGDGMPGH 64

  Fly    67 ICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIVGCE---- 127
            ||..|.:..::.:.|:..|:::.....|........|.|.:         |..|..:|..:
  Fly    65 ICLECRLLFEHCYRFKQMCKRAETLLRQYPLTGNWPSPLEK---------PRAPMTMVASKKLLV 120

  Fly   128 ------DPLDT-----NVTKLDANR---PDVKTDIDEPTDGKATNGQESEP---------LQEVF 169
                  :|.:|     |.....:::   .||:.........:...|....|         :....
  Fly   121 VPAKTAEPSETPKKLLNTMAKSSSQVIIEDVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQ 185

  Fly   170 EITMNDIKT--EDEVS-IQETFEDAFD-----------------------------------EEN 196
            |::|:|:::  ||..| :::.|.|...                                   :.:
  Fly   186 ELSMDDVQSMLEDMASELEKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAPVEPRLATPKVKRD 250

  Fly   197 DNNNTD--SEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLL-----CTECGVSYSTQKA 254
            |:.|..  :|..|||.    ..:|||:|           ..|.:.:.     |.:|..|:..|:.
  Fly   251 DSGNVAIVTEVLDSDL----PLDDQDDP-----------TKNAEKVATDVFPCPDCERSFPLQQL 300

  Fly   255 LARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHM 319
            |..|...|......|    |..|.:.|.:...|..|...|||||||||.:|.||:|....|..|.
  Fly   301 LEIHRLNHTRSRSFQ----CLLCEKSFFSKYDLAKHNFVHTGERPFKCAICSKAFTRKALLHRHE 361

  Fly   320 HTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPF 384
            .||.:.....|..|:|.|.:|..:..|.:||..:||::|..|.::||...||:.|..:|....||
  Fly   362 RTHTDVPKFICVYCEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERHETVHSTNLPF 426

  Fly   385 KCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAF 449
            .|          ||                  |::||...|.:.:|...|:|.:.:.|:.|.:::
  Fly   427 PC----------QH------------------CERSFSTASKLARHLVAHAGKRAYPCKYCHKSY 463

  Fly   450 SHNHHLKSHLRIH--TGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQS 512
            ..:|||..|||.|  |.:..:.|.:|...:|....|:.|.|.|...:   .||..|.|..:...|
  Fly   464 MLSHHLSRHLRTHTQTSDASFVCSECKVSYSNYNDLLDHALIHATAS---LKCPMCRKQIEDIDS 525

  Fly   513 LRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHI-TSHKIRPHP 558
            :..|...||..:.    |.|..||..|..:|.|.:|| ..|.:...|
  Fly   526 VESHMDQHKQSER----HACEFCDHIFLTQKCLQRHIEDDHVVEMEP 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	18/92 (20%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	14/23 (61%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	7/23 (30%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		COG5048	<395..583	CDD:227381	45/167 (27%)
		zf-C2H2	412..434	CDD:278523	5/21 (24%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..451	CDD:290200	5/24 (21%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	9/25 (36%)
		C2H2 Zn finger	470..486	CDD:275368	4/15 (27%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370	8/20 (40%)
		C2H2 Zn finger	559..579	CDD:275370	146/632 (23%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	18/91 (20%)
		COG5048	<281..506	CDD:227381	76/256 (30%)
		C2H2 Zn finger	288..308	CDD:275368	6/19 (32%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..353	CDD:290200	14/24 (58%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..388	CDD:275370	5/15 (33%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..448	CDD:275368	8/47 (17%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		HARE-HTH	<566..625	CDD:294801	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3381
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050