DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and ZNF429

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_016882237.1	Gene:	ZNF429 / 353088	HGNCID:	20817	Length:	689	Species:	Homo sapiens

Alignment Length:	369	Identity:	136/369 - (36%)
Similarity:	200/369 - (54%)	Gaps:	39/369 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306
            |.|||.::|......:|...|.|    :||:.|..||:.|..::.||:|:|.||||:|:||..|.
Human   302 CDECGKTFSISSTFTKHKIIHTE----EKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECG 362

  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYK-------------- 357
            ||:....||..|...|..||.:||.:|.|.|.....|..|.:.||||.|||
Human   363 KAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLTRHKKIHTGEEPYKFEKCGRVFTCSSTL 427

  Fly   358 --------------CPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNG 408
                          |.:|.:.|..:|.|..|.|:|.||:|:||..|||.|.::.||.:|.|:|.|
Human   428 TQDKKIHTGEKPYNCEECGKVFTYSSTLTRHKRIHTEEKPYKCNECGKAFNRSSHLTSHRRIHTG 492

  Fly   409 DRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQC 473
            ::.:||.:|.|:|.:.||:..|::.|||.||:||||||:||..:..|..|.:||||||||||::|
Human   493 EKPYKCEECGKAFKQSSNLNSHKKIHSGEKPYKCEECGKAFILSSRLTQHKKIHTGEKPYKCEEC 557

  Fly   474 GKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVR 538
            ||.|:.:..|.:|...|  ..::|:||.||.||:....:|..|:|.|.. ::|   ::|..|...
Human   558 GKAFNRSSRLTQHKKIH--TGEKPYKCKQCDKAFTHSSNLSSHKKIHSG-EKP---YKCEECGKA 616

  Fly   539 FALKKTLDKHITSH-KIRPHPCPQCPEGFFSQKSLKKHLRLHNL 581
            |.....|.:|...| :.:|:.|.:|.:.|.....|.:|.::|.:
Human   617 FNRSSRLTQHKKIHTREKPYKCEECAKAFTRSSRLTQHKKIHRM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	14/23 (61%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	11/51 (22%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	71/188 (38%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	15/24 (63%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	5/19 (26%)
ZNF429	XP_016882237.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.050