DRSC/TRiP Functional Genomics Resources

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Protein Alignment Meics and esg

DIOPT Version :9

Sequence 1:NP_524062.1 Gene:Meics / 39539 FlyBaseID:FBgn0025874 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_476600.1 Gene:esg / 34903 FlyBaseID:FBgn0001981 Length:470 Species:Drosophila melanogaster


Alignment Length:503 Identity:101/503 - (20%)
Similarity:164/503 - (32%) Gaps:172/503 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 EDPL-DTNVTKLDANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTEDEVSIQETFED 190
            ||.| :.|.:|....:..|....:.|.:...|..:..:...:..|| :.:..:|:.:::.:..| 
  Fly     5 EDMLVEKNYSKCPLKKRPVNYQFEAPQNHSNTPNEPQDLCVKKMEI-LEENPSEELINVSDCCE- 67

  Fly   191 AFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKAL 255
              ||..|.::||.|..:.:...|....|.|.               ||:........:.....|.
  Fly    68 --DEGVDVDHTDDEHIEEEDEDVDVDVDSDP---------------NQTQAAALAAAAAVAAAAA 115

  Fly   256 ARHVA------KHKEQGDTQKPHLCDFCGRGFRT-NAQLTTHRRRHTGER--PFKCPLC------ 305
            |..|.      |:........|:..:|    :|| |.|         |.:  |.:..|.      
  Fly   116 ASVVVPTPTYPKYPWNNFHMSPYTAEF----YRTINQQ---------GHQILPLRGDLIAPSSPS 167

  Fly   306 ---------PKAYTHG----------------------------------PTLKSHMHTHDEEKG 327
                     |..|.||                                  |:|..:.|||.    
  Fly   168 DSLGSLSPPPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHH---- 228

  Fly   328 HKCP----QCDKTFYTRGNL--------------------------------------------- 343
            |..|    ..:.::|:..::                                             
  Fly   229 HHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPET 293

  Fly   344 --RAHIQRHTGERP-YKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRV 405
              .|..::...:.| |:||||.::::..|||..|.:.|       |.......|:          
  Fly   294 MPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFH-------CPAAEGNQVK---------- 341

  Fly   406 HNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKC 470
                :.|.|.||||::.....:..|.|||:  .|.||..||:|||....|:.|:|.||||||:.|
  Fly   342 ----KSFSCKDCDKTYVSLGALKMHIRTHT--LPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSC 400

  Fly   471 DQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEK 518
            ..|.:.|:...:|..|...|.|  .:.:.|:.|.|.:.....|..|.:
  Fly   401 QHCHRAFADRSNLRAHLQTHSD--IKKYSCTSCSKTFSRMSLLTKHSE 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeicsNP_524062.1 zf-AD 21..95 CDD:285071
C2H2 Zn finger 242..262 CDD:275368 3/25 (12%)
C2H2 Zn finger 274..294 CDD:275368 5/20 (25%)
zf-H2C2_2 287..311 CDD:290200 5/40 (13%)
C2H2 Zn finger 302..322 CDD:275368 8/68 (12%)
C2H2 Zn finger 330..350 CDD:275368 3/70 (4%)
zf-H2C2_2 342..366 CDD:290200 7/71 (10%)
C2H2 Zn finger 358..378 CDD:275368 8/19 (42%)
C2H2 Zn finger 386..406 CDD:275368 2/19 (11%)
COG5048 <395..583 CDD:227381 39/124 (31%)
zf-C2H2 412..434 CDD:278523 8/21 (38%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 426..451 CDD:290200 11/24 (46%)
C2H2 Zn finger 442..462 CDD:275368 9/19 (47%)
zf-H2C2_2 454..478 CDD:290200 11/23 (48%)
C2H2 Zn finger 470..486 CDD:275368 4/15 (27%)
C2H2 Zn finger 500..520 CDD:275368 5/19 (26%)
C2H2 Zn finger 532..552 CDD:275370
C2H2 Zn finger 559..579 CDD:275370
esgNP_476600.1 zf-C2H2 309..331 CDD:278523 9/21 (43%)
C2H2 Zn finger 311..331 CDD:275370 8/19 (42%)
zf-C2H2 344..366 CDD:278523 8/21 (38%)
C2H2 Zn finger 346..366 CDD:275368 7/19 (37%)
zf-C2H2 370..392 CDD:278523 10/21 (48%)
C2H2 Zn finger 372..392 CDD:275368 9/19 (47%)
zf-H2C2_2 385..408 CDD:290200 11/22 (50%)
zf-C2H2 398..420 CDD:278523 5/21 (24%)
C2H2 Zn finger 400..420 CDD:275368 5/19 (26%)
C2H2 Zn finger 428..444 CDD:275368 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24377
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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