DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and CG9215

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_573045.1	Gene:	CG9215 / 32494	FlyBaseID:	FBgn0030659	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	134/551 - (24%)
Similarity:	208/551 - (37%)	Gaps:	130/551 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSGKMERSVDASMGKNCRAC----AEHSSILVDLFSKEISDPPIWEMLNSILPEI--C------- 56
            |:....|.||  :|..|..|    .|.|||..       .||....||  ||.:|  |
  Fly     2 SNNLQPRVVD--LGVACLVCLAEEPEASSIYG-------HDPESPHML--ILDKIRCCTSLQLDS 55

  Fly    57 ---RVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPL 118
               :::|  .|.|||..|.:....::.|..||....:.|.     ..|.|..:.:........|.
  Fly    56 SPSQLQR--WPDKICKQCHLELSVSYRFHEKCTAVQKLFR-----SASRSTSTSAVFAAAAAAPP 113

  Fly   119 IPFEIVGCEDPLDTNVTKLDANRPDVKTDID--------EPTDGKATNG---QESEPLQEVFE-- 170
            .|..:...::.|     |||..:..|:....        ||....:.:|   ..:||.::|.|
  Fly   114 APMLVDKQQEQL-----KLDLEQAHVRLPATLKIRRLNVEPCSSSSVSGTITTSTEPSEDVKEEK 173

  Fly   171 -------------ITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQ--- 219
                         :::||.:.:|.::.|...:|. .::.|.:...::..:.|.|...:|.:.
  Fly   174 TDSLSLIPDGAMVLSLNDFQAQDSITQQAEEKDP-KKQQDEDEGQAKMLELDPWDDENTPEHLYE 237

  Fly   220 -DEPWIPGGGGRQTVGGN-----------NQSLLCTECGVSYSTQ-KALARHVAKHKEQGDTQK- 270
             :.|.|     .::|..:           ||....|...||.:.: :.|..:|....:.|.|.|
  Fly   238 IETPLI-----EESVVASPPLPLPPTHPANQQKKRTYRRVSPNVKHEKLTANVDDDFKAGSTTKR 297

  Fly   271 ------PHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHK 329
                  |.:||.||..::....|..|.|||..|||:.|.:|.||
  Fly   298 RNCERSPKICDVCGNTYKYQHALNAHMRRHNNERPYSCEVCQKA--------------------- 341

  Fly   330 CPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFV 394
                   |.:...||.|::.|||::||.|..|.:.|:.....|.|.|:|..|||:.||:|.|||.
  Fly   342 -------FISNVELRRHMRVHTGQKPYSCRHCERRFSDFGSSKKHERIHTGERPYVCEVCNKGFA 399

  Fly   395 QNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGI---KPFKCEECGQAFSHNHHLK 456
            ....|..|.|.|.|.:||:|..|||.|.:|:.:..|...|.|.   :.........|.|.|.:..
  Fly   400 YAHVLSAHRRTHTGKKQFQCTQCDKGFTKKTYLSAHMEQHRGSGNGEASVASSSADASSRNQNAS 464

  Fly   457 SHLRIHTGEKPYKCDQCGKGFSANQSLMKHT 487
            :.     .|...|..|..:.||.:...::.|
  Fly   465 AR-----KESARKQQQIPESFSLDSVELEQT 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	24/89 (27%)
		C2H2 Zn finger	242..262	CDD:275368	5/20 (25%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	4/19 (21%)
		C2H2 Zn finger	330..350	CDD:275368	4/19 (21%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	25/96 (26%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	4/27 (15%)
		C2H2 Zn finger	442..462	CDD:275368	3/19 (16%)
		zf-H2C2_2	454..478	CDD:290200	3/23 (13%)
		C2H2 Zn finger	470..486	CDD:275368	3/15 (20%)
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
CG9215	NP_573045.1	zf-AD	16..92	CDD:285071	23/86 (27%)
		DUF2117	165..>273	CDD:303038	18/113 (16%)
		COG5048	<303..439	CDD:227381	56/163 (34%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		zf-H2C2_2	319..344	CDD:290200	13/52 (25%)
		zf-C2H2	333..355	CDD:278523	8/49 (16%)
		C2H2 Zn finger	335..355	CDD:275368	8/47 (17%)
		zf-H2C2_2	347..371	CDD:290200	10/23 (43%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..400	CDD:290200	13/24 (54%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	404..427	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840