DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and dwg

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	155/576 - (26%)
Similarity:	238/576 - (41%)	Gaps:	125/576 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NC----RACAEHSSIL--VDLFSKEISDPPIWEMLN-----SILPEICRVKRDEMPQKICPTCLV 73
            ||    |||..|..:.  :||.|:  ....:..|||     |..|:    ....|||.||..||.
  Fly    13 NCRTCTRACKLHKPLQEEIDLGSE--GSTTLASMLNYCTGLSFEPQ----DGAAMPQHICLHCLQ 71

  Fly    74 AAQNAFHFRHKCEQSFQFFSQLLQLDKS-----------NSNLSRSHCRR----GTMNPLIPFEI 123
            ..:.||:|:.....|.:...  |.||::           :.|.|:.|.::    .:....:..|:
  Fly    72 LLEQAFNFKRMVIDSDELLR--LGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEM 134

  Fly   124 VGCEDPLDTNVTKLD----------------------ANRPDVKTDIDEPTDGKATNGQESE--- 163
            :..|   ..||..||                      ....|...::.|.....|.:|.:.|
  Fly   135 LNEE---QENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHI 196

  Fly   164 PLQEVF-----EITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPW 223
            .::.|.     |:....||.|.|..:.|  ||.|:..||:...|:..:  .|..|
  Fly   197 TMESVHEFQPAEVEYVTIKNEFETIVTE--EDEFEVMNDSGAHDAILD--CQMIV---------- 247

  Fly   224 IPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHL-------C---DFCG 278
            ||..|....|.|.....|                       :||.::.||       |   ||..
  Fly   248 IPAEGAIDEVIGEETLEL-----------------------EGDGREEHLLPEAEDVCEDEDFLE 289

  Fly   279 RGFRTNAQLTTHRRRHTGER-PFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGN 342
            ... .:|..|      .||. |:.|.:|.||:.....|..||.:|.:||.::|.:|.|......|
  Fly   290 ESL-DSAPPT------AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRN 347

  Fly   343 LRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHN 407
            .:.|:..||..:|::|..|.:.:...|.|.:|.|.|.|::|:.|:.||:|:....||..|...|.
  Fly   348 YKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHT 412

  Fly   408 GDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQ 472
            |:|.:.|..|||::::.|::.:|:.:|:|.|.|.||.||...|.....|.|:.:|:|.|.:|||.
  Fly   413 GERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDV 477

  Fly   473 CGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKT 528
            ||..|:...:|..|...|  :.::||||..|.||:.|::.|..|.:.| |.:.|.|
  Fly   478 CGHAFTFTSNLNAHVRLH--SGEKPFKCEVCVKAFPTKKRLASHMRVH-NKESPVT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	24/84 (29%)
		C2H2 Zn finger	242..262	CDD:275368	0/19 (0%)
		C2H2 Zn finger	274..294	CDD:275368	5/22 (23%)
		zf-H2C2_2	287..311	CDD:290200	8/24 (33%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	7/23 (30%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	49/134 (37%)
		zf-C2H2	412..434	CDD:278523	6/21 (29%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..451	CDD:290200	9/24 (38%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	10/23 (43%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	24/82 (29%)
		COG5048	<297..451	CDD:227381	53/159 (33%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	50/137 (36%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	9/24 (38%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960