DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Plag1

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001008317.1	Gene:	Plag1 / 297804	RGDID:	1305286	Length:	499	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	102/407 - (25%)
Similarity:	159/407 - (39%)	Gaps:	103/407 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 TQKALARHVAKHKE-QGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPL--CPKAYTHG 312
            ||||.:   .|.|. :...:|...|..|.:.|.:..:|..|...||||||:||..  |.||:...
  Rat    15 TQKAPS---GKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFVSK 76

  Fly   313 PTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRH-TGERPYKCPDCPQTFAKNSGLKLHSR 376
            ..|:.||.||..||.|||..|:|.|:.:.:|:.|:..| ..:..:||.:|.:::....|.|.|..
  Rat    77 YKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLA 141

  Fly   377 LH-KEERPFKCELCGKGFVQNQHLITHLRVHNG-------DRQFKCPDCDKSFFEKSNMMKHQRT 433
            || .......|::|.:.|.....|:.||:.|.|       :::.:|..|::.|:.:.::.:|...
  Rat   142 LHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVV 206

  Fly   434 HSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPF 498
            |:|.|.|.|:.|.|.|....||..|::                .|.||.|:|.....||..| ||
  Rat   207 HTGRKDFLCQYCAQRFGRKDHLTRHMK----------------KSHNQELLKVKTEPVDFLD-PF 254

  Fly   499 KCS-------------QCPKA---------------YDTQ-QSLRGHEKTHKN----------PD 524
            .|:             ..|.:               |:|. ||::....||:.          |.
  Rat   255 TCNMSVPIKDELLPVMSLPSSELLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPI 319

  Fly   525 EPKTLH-------QCPHCDVRFAL-------------------------KKTLDKHITSHKIRPH 557
            :..|:|       :||.....:|:                         ..:.|...:|.|:...
  Rat   320 DMDTVHPSHHLAFKCPFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLE 384

  Fly   558 PCPQCPEGFFSQKSLKK 574
            |....|:......||.|
  Rat   385 PQSGSPDDGAGDLSLSK 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	4/10 (40%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	13/25 (52%)
		C2H2 Zn finger	302..322	CDD:275368	7/21 (33%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	6/24 (25%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		COG5048	<395..583	CDD:227381	52/258 (20%)
		zf-C2H2	412..434	CDD:278523	4/21 (19%)
		C2H2 Zn finger	414..434	CDD:275368	4/19 (21%)
		zf-H2C2_2	426..451	CDD:290200	9/24 (38%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	3/23 (13%)
		C2H2 Zn finger	470..486	CDD:275368	4/15 (27%)
		C2H2 Zn finger	500..520	CDD:275368	6/48 (13%)
		C2H2 Zn finger	532..552	CDD:275370	4/44 (9%)
		C2H2 Zn finger	559..579	CDD:275370	4/16 (25%)
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		6/20 (30%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		25/71 (35%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	5/19 (26%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		65/216 (30%)
		SFP1	<58..139	CDD:227516	30/80 (38%)
		C2H2 Zn finger	64..86	CDD:275368	7/21 (33%)
		zf-H2C2_2	79..103	CDD:404364	13/23 (57%)
		C2H2 Zn finger	94..114	CDD:275368	6/19 (32%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	4/19 (21%)
		C2H2 Zn finger	215..233	CDD:275368	7/17 (41%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		27/160 (17%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		22/140 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..400		6/35 (17%)
		Massively activates transcription. /evidence=ECO:0000250	384..499		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000