DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and ZNF789

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_998768.2	Gene:	ZNF789 / 285989	HGNCID:	27801	Length:	425	Species:	Homo sapiens

Alignment Length:	368	Identity:	112/368 - (30%)
Similarity:	167/368 - (45%)	Gaps:	72/368 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QES-EPLQEVFEITMNDIKTEDEV-SIQETFEDAFDEEN----DNNNTDSEREDSDQWTVGSTED 218
            ||| |.|.|...      |.::.| |.:.||..:.||.:    .|.|...::....:|..|..::
Human   119 QESAEKLSEKLH------KCKEFVDSCRLTFPTSGDEYSRGFLQNLNLIQDQNAQTRWKQGRYDE 177

  Fly   219 QDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRT 283
            ..:|:            |.:|||       ...::.|.|           .|.:.|..||:..|.
Human   178 DGKPF------------NQRSLL-------LGHERILTR-----------AKSYECSECGKVIRR 212

  Fly   284 NAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQ 348
            .|....|:|.|..|.||:|.:|.:|                            |..|..|..|.|
Human   213 KAWFDQHQRIHFLENPFECKVCGQA----------------------------FRQRSALTVHKQ 249

  Fly   349 RHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFK 413
            .|...:||:|.||.:.|.:.:.|..|.|:|.:|:|:||..|.|.|.||..||.|..:|:|:::.|
Human   250 CHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHK 314

  Fly   414 CPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFS 478
            |.:|.|:|...|.::.||:.||.....||.||||:|..|..|..|.||||.|:.::|.:|||.||
Human   315 CLECGKAFGRHSTLLCHQQIHSKPNTHKCSECGQSFGRNVDLIQHQRIHTKEEFFQCGECGKTFS 379

  Fly   479 ANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHK 521
            ..::|.:|.:.|  ...:|::|..|.|::....|...|:.|||
Human   380 FKRNLFRHQVIH--TGSQPYQCVICGKSFKWHTSFIKHQGTHK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	2/19 (11%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	9/23 (39%)
		C2H2 Zn finger	302..322	CDD:275368	3/19 (16%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	50/127 (39%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	442..462	CDD:275368	10/19 (53%)
		zf-H2C2_2	454..478	CDD:290200	11/23 (48%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
ZNF789	NP_998768.2	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<179..303	CDD:227381	49/181 (27%)
		C2H2 Zn finger	179..195	CDD:275368	5/34 (15%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	8/47 (17%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	271..296	CDD:290200	11/24 (46%)
		COG5048	<283..420	CDD:227381	54/138 (39%)
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368	10/19 (53%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910