DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp317

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_766506.4	Gene:	Zfp317 / 244713	MGIID:	107775	Length:	607	Species:	Mus musculus

Alignment Length:	597	Identity:	165/597 - (27%)
Similarity:	252/597 - (42%)	Gaps:	131/597 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CRVKRDEMPQKICPTCLVAAQN-AFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLI 119
            |.....:.|.::|....|..|: |..|..|         :...||.|...|.:
Mouse    43 CHAPEPDTPARVCSQESVTFQDIAVDFTEK---------EWPLLDSSQRKLYK------------ 86

  Fly   120 PFEIVGCEDPLDTNVTKLDA-----NRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTE 179
                    |.:..|.:.|.:     .:|.:.:.:::..|.:    .|...:|:.   ...|..|.
Mouse    87 --------DVMLENYSNLSSLGYQVGKPRLISHLEQEEDLR----MEERGIQQG---PSPDWGTT 136

  Fly   180 DEVSIQETFEDAFDEENDNN---NTDSEREDSDQWT-------VGSTEDQDEPWIPGGGGRQTVG 234
            .:|......||.|.:|..::   .|....|.|.:::       :|       |.:....||.|
Mouse   137 SKVKWSILLEDIFGKEASDDVRLETSHLLETSSEFSHLCEVFDIG-------PHLAQPVGRPT-- 192

  Fly   235 GNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERP 299
             ..:......|||....      |:.:|....|.:|.|.|..|.:.|.|:|.||.|.|.||||:|
Mouse   193 -GKRPYHHHSCGVKNRI------HLTQHMSMNDGRKWHKCHQCQKAFTTSASLTRHHRIHTGEKP 250

  Fly   300 FKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQT 364
            ::|..|.||:.....|:||..||.:||...|.||...|.|...|:.|::.|||||||||.:|.:.
Mouse   251 YECSSCGKAFNDPSALRSHTRTHLKEKPFDCSQCSNAFRTLSALKIHMRVHTGERPYKCDECGKA 315

  Fly   365 FAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNM-- 427
            :.::..|..|.|.|..|||::|:.|||.|....||..|:|.|.|::.::|..|.|:|..|||.
Mouse   316 YGRSCHLIAHKRTHTGERPYECQDCGKAFQHPSHLKEHVRNHTGEKPYECTQCGKAFRWKSNFNL 380

  Fly   428 --------------------------MKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEK 466
                                      .||.|.|...||.:|.:||:.|.:...||:|:..||||:
Mouse   381 HKKNHMVEKTYECKECGKSFSDLLSRRKHMRIHIVKKPVECHQCGKTFRNQSILKTHMNSHTGER 445

  Fly   467 PYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCS----------------------------QC 503
            ||.||.|||.|||:.:|..|...|  ..:|.::|:                            ||
Mouse   446 PYGCDLCGKAFSASSNLTAHRKIH--TQERHYECTSCGKVFGDYLSRRRHMSIHLVKKRVDCRQC 508

  Fly   504 PKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFF 567
            .||:..|.:|:.|.::|.. ::|   ::|.||...|::...|:.|...|. .:|:.|..|.:.|.
Mouse   509 GKAFRNQSTLKTHMRSHTG-EKP---YECDHCGKAFSIGSNLNVHRRIHTGEKPYECLICGKAFS 569

  Fly   568 SQKSLKKHLRLH 579
            ...||:.|::.|
Mouse   570 DHSSLRSHVKTH 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	8/39 (21%)
		C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	274..294	CDD:275368	9/19 (47%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	12/23 (52%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	69/242 (29%)
		zf-C2H2	412..434	CDD:278523	10/49 (20%)
		C2H2 Zn finger	414..434	CDD:275368	10/47 (21%)
		zf-H2C2_2	426..451	CDD:290200	11/52 (21%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	14/23 (61%)
		C2H2 Zn finger	470..486	CDD:275368	9/15 (60%)
		C2H2 Zn finger	500..520	CDD:275368	8/47 (17%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	6/19 (32%)
Zfp317	NP_766506.4	KRAB	60..118	CDD:214630	13/86 (15%)
		COG5048	223..570	CDD:227381	120/352 (34%)
		C2H2 Zn finger	225..245	CDD:275368	9/19 (47%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	3/19 (16%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	10/19 (53%)
		C2H2 Zn finger	477..497	CDD:275368	1/19 (5%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000