DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and Zfp668

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001349118.1	Gene:	Zfp668 / 244219	MGIID:	2442943	Length:	619	Species:	Mus musculus

Alignment Length:	471	Identity:	136/471 - (28%)
Similarity:	203/471 - (43%)	Gaps:	125/471 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 GRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRR 293
            ||...|  .:...|.|||..:.....|..|:|.|.    .:.|..|..|.:.:.|.::|..|:|.
Mouse   103 GRSHTG--EKPFPCPECGRRFMQPVCLRVHLASHA----GELPFRCTHCPKAYGTLSKLKIHQRG 161

  Fly   294 HTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKC 358
            ||||||:.||.|.|::......:.|..||...:.:.|.:|.|.:....:||.|.:.||||||:.|
Mouse   162 HTGERPYACPDCGKSFADPSVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLC 226

  Fly   359 PDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFE 423
            .:|.::|:::|.|..|.|:|..::|::|..|||||.|.....:|.|.|:|::.|.||.|.:.|.:
Mouse   227 SECGKSFSRSSSLTCHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSD 291

  Fly   424 KSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTL 488
            .|:..:|||.|.|:||::||:||:.|.....|..|.|:|||::|:||.||.|.|.|:..|.:|.|
Mouse   292 PSSFRRHQRAHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHAL 356

  Fly   489 WH--------------------------VDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKN----- 522
            .|                          :.:.:|||.|:.|.|::....|||.||:||::
Mouse   357 VHSGQRPFRCEECGRAFAERASLTKHSRMHSGERPFHCNACGKSFVVLSSLRKHERTHRSNETTG 421

  Fly   523 -----------------------------------------PDE--------------------- 525
                                                     |.|
Mouse   422 AAPQQELVLGLALPVGVVGEGSAAPVAGAGVGDAPAGLLGLPPESGGVVATQWQVVGMTVEHVEC 486

  Fly   526 --------PKTLHQ-----------------CPHCDVRFALKKTLDKHITSH-KIRPHPCPQCPE 564
                    |.||..                 |..|...|:....|.:|..|| ::||.||.||.:
Mouse   487 QDAGVGEAPSTLGDAGEVGGEETDEKPPQFVCRECKETFSTLTLLRRHERSHPELRPFPCTQCGK 551

  Fly   565 GFFSQKSLKKHLRLHN 580
            .|..:..|:||.|.|:
Mouse   552 SFSDRAGLRKHSRTHS 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	78/305 (26%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	8/19 (42%)
Zfp668	NP_001349118.1	C2H2 Zn finger	24..44	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..74
		COG5048	65..419	CDD:227381	112/321 (35%)
		C2H2 Zn finger	86..106	CDD:275368	2/2 (100%)
		C2H2 Zn finger	114..134	CDD:275368	7/19 (37%)
		C2H2 Zn finger	142..162	CDD:275368	6/19 (32%)
		C2H2 Zn finger	170..190	CDD:275368	5/19 (26%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		COG5048	248..598	CDD:227381	85/320 (27%)
		C2H2 Zn finger	254..274	CDD:275368	9/19 (47%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)
		C2H2 Zn finger	338..358	CDD:275368	9/19 (47%)
		C2H2 Zn finger	366..386	CDD:275368	0/19 (0%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513		3/21 (14%)
		C2H2 Zn finger	518..538	CDD:275368	5/19 (26%)
		C2H2 Zn finger	546..566	CDD:275368	8/19 (42%)
		C2H2 Zn finger	574..594	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000