DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Meics and Zfp53

DIOPT Version :10

Sequence 1:NP_524062.1 Gene:Meics / 39539 FlyBaseID:FBgn0025874 Length:583 Species:Drosophila melanogaster
Sequence 2:NP_038871.1 Gene:Zfp53 / 24132 MGIID:99200 Length:652 Species:Mus musculus


Alignment Length:682 Identity:188/682 - (27%)
Similarity:302/682 - (44%) Gaps:172/682 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 RSSGKMERSVDASMGKNCRACAEHSSILVDLFSKE-ISDPPIWEMLNS--ILPEICRVKRD---E 62
            :.:.||||  ..::.|:....|.:|     ||.|| |.:....||..|  |:.:......|   |
Mouse     5 KETWKMER--QEAVAKDPGPQASYS-----LFFKEKIKEETQKEMAGSPLIMSQRLLTFGDVAVE 62

  Fly    63 MPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIVGCE 127
            .||:.. .||.:||.|.:.    :...:.:|.|:.::        ::|...|::..:..|...|:
Mouse    63 FPQEEW-ECLDSAQRALYI----DVMLENYSNLVSVE--------NYCISDTVHQHVKTEKESCQ 114

  Fly   128 --------------------DPLDTNVTKLDANRPDVKTDIDEPTDGKATN-GQE---SEPLQEV 168
                                |.::|:.....:...|...|:......|:|: |:|   ||..::.
Mouse   115 GNELGEMLHEPTNCALYIRRDTIETSNNYRCSKDRDGSVDLLNQDRHKSTHTGEELCKSEDCEKS 179

  Fly   169 FEITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSEREDSDQWT-----------VGSTEDQDEP 222
            ..::.|  .||:    |..:.        .|...|:.|..|.::           :|.|..|   
Mouse   180 LSLSSN--LTEN----QRLYA--------ANKLQSQGEYDDDFSSVYSLMQQTIYIGDTPHQ--- 227

  Fly   223 WIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQL 287
                               |.:|...:||..:|..|...|    ..:||:.|..||:.|.....|
Mouse   228 -------------------CEKCRKCFSTASSLTVHKRIH----TGKKPYKCSVCGKSFTQCTNL 269

  Fly   288 TTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTF--------------- 337
            .||:|.||||:|:||..|.|::.....||||...|..|:.:||.:|||:|               
Mouse   270 KTHQRLHTGEKPYKCKECGKSFPQLSALKSHQKIHTGERPYKCKECDKSFAHCSSFRRHQKTHRA 334

  Fly   338 -------------YTRGNLRAHIQRHTGERPYKCPDCPQTF--------------------AKNS 369
                         :...:||:|.:.||||:||||.:|.::|                    .|..
Mouse   335 EEHCSCPECGKVLHQLSHLRSHYRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYKCKEC 399

  Fly   370 G--------LKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSN 426
            |        ||.|.|:|..|:|:|||:|.|.|..|..|.|||::|.|::.|||.:|||||.:.|:
Mouse   400 GKSFLELSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKPFKCRECDKSFTKCSH 464

  Fly   427 MMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHV 491
            :.:||..|:|.||::|:||.::|:....|::|.:||||||||||.:|.|.|....:|:.|.  .|
Mouse   465 LRRHQSVHTGEKPYRCKECDKSFTECSTLRAHQKIHTGEKPYKCRECDKSFIQRSNLIIHQ--RV 527

  Fly   492 DNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK--- 553
            ...:||:.|.:|.|::....:|:.|:|.|.. ::|   ::|..|:..|    |.|.|:.:|:   
Mouse   528 HTGERPYICKECGKSFTKCSTLQIHQKIHTG-EKP---YKCMECNKSF----TQDSHLRTHQRVH 584

  Fly   554 --IRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583
              .||:.|.:|.:.|.....|:.|.::|..:|
Mouse   585 TGERPYICKECGKSFTRCSYLRAHQKIHTGEK 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeicsNP_524062.1 zf-AD 20..95 CDD:462262 21/80 (26%)
C2H2 Zn finger 242..262 CDD:275368 6/19 (32%)
C2H2 Zn finger 274..294 CDD:275368 8/19 (42%)
SFP1 <296..374 CDD:227516 36/133 (27%)
COG5048 <299..486 CDD:227381 87/242 (36%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
C2H2 Zn finger 330..350 CDD:275368 8/47 (17%)
C2H2 Zn finger 358..378 CDD:275368 9/47 (19%)
C2H2 Zn finger 386..406 CDD:275368 10/19 (53%)
COG5048 <395..583 CDD:227381 69/192 (36%)
C2H2 Zn finger 414..434 CDD:275368 9/19 (47%)
C2H2 Zn finger 442..462 CDD:275368 6/19 (32%)
C2H2 Zn finger 470..486 CDD:275368 5/15 (33%)
C2H2 Zn finger 500..520 CDD:275368 6/19 (32%)
C2H2 Zn finger 532..552 CDD:275370 6/19 (32%)
C2H2 Zn finger 559..579 CDD:275370 5/19 (26%)
Zfp53NP_038871.1 KRAB 53..93 CDD:460171 11/44 (25%)
COG5048 223..627 CDD:227381 138/430 (32%)
C2H2 Zn finger 228..248 CDD:275368 6/19 (32%)
C2H2 Zn finger 256..276 CDD:275368 8/19 (42%)
C2H2 Zn finger 284..304 CDD:275368 7/19 (37%)
C2H2 Zn finger 312..332 CDD:275368 5/19 (26%)
C2H2 Zn finger 340..360 CDD:275368 3/19 (16%)
C2H2 Zn finger 370..388 CDD:275368 2/17 (12%)
C2H2 Zn finger 396..416 CDD:275368 6/19 (32%)
C2H2 Zn finger 424..444 CDD:275368 10/19 (53%)
C2H2 Zn finger 452..472 CDD:275368 9/19 (47%)
C2H2 Zn finger 480..500 CDD:275368 6/19 (32%)
C2H2 Zn finger 508..528 CDD:275368 6/21 (29%)
C2H2 Zn finger 536..556 CDD:275368 6/19 (32%)
C2H2 Zn finger 564..584 CDD:275368 7/23 (30%)
C2H2 Zn finger 592..612 CDD:275368 5/19 (26%)
C2H2 Zn finger 620..640 CDD:275368
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.