DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp26

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	367	Identity:	140/367 - (38%)
Similarity:	210/367 - (57%)	Gaps:	31/367 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CTECGVSYSTQKALARHVAKH--------KEQGDT----------------QKPHLCDFCGRGFR 282
            |.|||.:::.:.:|..|:.:|        ||.|.|                :||:.||.||..|.
Mouse   380 CKECGKAFTERSSLIVHLRQHTREKSYECKECGKTFIQPSRLTEHMRSHTGEKPYQCDQCGNAFA 444

  Fly   283 TNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHI 347
            :::.||||.|.||||:||:|.:|.||:|....|..|:.||..||.::|..|.|.|..|..|..|:
Mouse   445 SSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGKAFSGRSWLTIHL 509

  Fly   348 QRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQF 412
            ::|||||||.|.:|.:.|...:.|..|.:.|..|:||:|::|.:.|..:..|.||.|:|.|.:.:
Mouse   510 RKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNSSCLKTHFRIHTGIKPY 574

  Fly   413 KCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGF 477
            ||..|.|:|..:|.:.||...|:|.||::|:|||:|||.:..|..|:||||||||::|.||||..
Mouse   575 KCNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKAL 639

  Fly   478 SANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALK 542
            :.:.||:.|...|  ..::||:|:||.|.:.....||.|.:||.. ::|   ::|..|...|..:
Mouse   640 AHSSSLVGHLRTH--TGEKPFECNQCDKTFTRSSYLRIHMRTHTG-EKP---YECKECGKTFPER 698

  Fly   543 KTLDKHITSHK-IRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583
            ..|.|||.:|. .||:.|.:|.:||.|...|..|::.|:.::
Mouse   699 SCLTKHIRTHTGERPYECKECGKGFISFAQLTVHIKTHSSER 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	10/19 (53%)
		zf-H2C2_2	287..311	CDD:290200	15/23 (65%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		COG5048	<395..583	CDD:227381	74/188 (39%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	10/19 (53%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630
		C2H2 Zn finger	297..317	CDD:275368
		COG5048	325..760	CDD:227381	140/367 (38%)
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	4/19 (21%)
		C2H2 Zn finger	436..456	CDD:275368	10/19 (53%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		COG5048	600..956	CDD:227381	58/147 (39%)
		C2H2 Zn finger	604..624	CDD:275368	10/19 (53%)
		C2H2 Zn finger	632..652	CDD:275368	8/19 (42%)
		C2H2 Zn finger	660..680	CDD:275368	7/19 (37%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	884..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000