DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp879

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_775563.1	Gene:	Zfp879 / 214779	MGIID:	3053099	Length:	563	Species:	Mus musculus

Alignment Length:	396	Identity:	136/396 - (34%)
Similarity:	199/396 - (50%)	Gaps:	43/396 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 EPWIPGGGGR----------QTVGGN--NQSLLCTECGVSYSTQKALARH--------------- 258
            :|.:..|||:          :.:|.|  .|...|..||..:....:|::|
Mouse   173 KPGVAAGGGKPHLQQYSVLFKQLGFNRARQLCKCNICGKVFFHSSSLSKHQRTHTGEKLYKCQGC 237

  Fly   259 ---------VAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPT 314
                     :|:|......:||:||..||:.|.....|..|:|.||||||::|..|.|.:....:
Mouse   238 RKAFSQRSSLAQHLRVHTGEKPYLCSDCGKAFSFTTSLIGHQRMHTGERPYECKECGKTFKGSSS 302

  Fly   315 LKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHK 379
            |.:|...|..||.:||.:|.:.|....:|..|.:.||||:||:|..|.:.|...|.|..|.|:|.
Mouse   303 LHNHQRIHTGEKPYKCNECGRAFSQCSSLIQHHRIHTGEKPYECSQCGKAFTSISRLSRHHRVHT 367

  Fly   380 EERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEE 444
            .|:||.|.:|||.|..:..|..|.|.|.|::.:.|.:|.|:|.:.|.:.:|||.|:|.||:||.|
Mouse   368 GEKPFHCNVCGKVFSYHSALTIHQRTHTGEKPYACKECGKAFSQSSALTQHQRIHTGEKPYKCAE 432

  Fly   445 CGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDT 509
            ||:|||....|..|.|||||||||.|.:|||.||::.::..|...|  ..::|:|||.|.||::.
Mouse   433 CGKAFSWLSRLNIHHRIHTGEKPYHCKECGKAFSSHSAVNTHRKIH--TGEKPYKCSDCEKAFNQ 495

  Fly   510 QQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFFSQKSLK 573
            ..:|..|::.|.. ::|   ..|..|...|....:|..|:..|. .||:.|..|.:.|....||.
Mouse   496 SSALIQHQRIHTG-EKP---FNCKVCGKAFRQSSSLMTHMRIHTGERPYRCEACGKAFSQSSSLA 556

  Fly   574 KHLRLH 579
            .|.:.|
Mouse   557 NHQKTH 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/43 (14%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	70/186 (38%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	14/24 (58%)
		C2H2 Zn finger	442..462	CDD:275368	10/19 (53%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	6/19 (32%)
Zfp879	NP_775563.1	KRAB	14..70	CDD:214630
		KRAB	14..53	CDD:279668
		zf-C2H2	204..226	CDD:278523	5/21 (24%)
		COG5048	205..558	CDD:227381	127/358 (35%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		zf-H2C2_2	218..243	CDD:290200	2/24 (8%)
		C2H2 Zn finger	234..254	CDD:275368	2/19 (11%)
		zf-H2C2_2	246..270	CDD:290200	8/23 (35%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		zf-H2C2_2	278..298	CDD:290200	11/19 (58%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..327	CDD:290200	8/21 (38%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		zf-H2C2_2	330..355	CDD:290200	11/24 (46%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		zf-H2C2_2	359..383	CDD:290200	12/23 (52%)
		C2H2 Zn finger	374..394	CDD:275368	8/19 (42%)
		zf-H2C2_2	386..411	CDD:290200	9/24 (38%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		zf-H2C2_2	414..438	CDD:290200	13/23 (57%)
		C2H2 Zn finger	430..450	CDD:275368	10/19 (53%)
		zf-H2C2_2	443..467	CDD:290200	16/23 (70%)
		C2H2 Zn finger	458..478	CDD:275368	7/19 (37%)
		zf-H2C2_2	470..495	CDD:290200	9/26 (35%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		zf-H2C2_2	498..523	CDD:290200	7/28 (25%)
		C2H2 Zn finger	514..534	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..551	CDD:290200	8/24 (33%)
		C2H2 Zn finger	542..562	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000