DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and Zfp729a

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_898969.2	Gene:	Zfp729a / 212281	MGIID:	3036250	Length:	973	Species:	Mus musculus

Alignment Length:	367	Identity:	131/367 - (35%)
Similarity:	187/367 - (50%)	Gaps:	39/367 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCP 306
            |.|||.::.....|::|...|:    .:||:.|:.||:.|...::|:.|::.|:||:||||.:|.
Mouse   261 CEECGKAFHISSFLSKHKIIHR----GEKPYKCEVCGKAFHYPSRLSNHKKIHSGEKPFKCEVCG 321

  Fly   307 KAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGL 371
            ||:.....|..|...|.||..:||..|.|.|.....|..|.:.||||:||||..|.:.|...|.|
Mouse   322 KAFRILSLLSKHKIIHTEENPYKCEVCGKAFDYPSRLSTHAKMHTGEKPYKCEVCQKAFRSLSSL 386

  Fly   372 KLHSRLHKE----------------------------ERPFKCELCGKGFVQNQHLITHLRVHNG 408
            ..|.|:|.|                            |:|:|||:|||.|..:..|..|..:|.|
Mouse   387 SKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRICAGEKPYKCEVCGKAFHVSSLLSKHRTIHTG 451

  Fly   409 DRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQC 473
            ::.:||..|.|:|:..|.:..|::.|:|.|||:||.||:||.....|..|.|||||||||||.:|
Mouse   452 EKLYKCEVCGKAFYYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKEC 516

  Fly   474 GKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVR 538
            ||.|.:..||.||...|  ..::|:||.:|.||:.....|..|:..| ..::|   ::|..|...
Mouse   517 GKAFRSLSSLSKHKRIH--TGEKPYKCEECGKAFHYPSLLSKHKIIH-TEEKP---YKCDVCGQA 575

  Fly   539 FALKKTLDKHITSHK-IRPHPCPQCPEGFFSQKSLKKHLRLH 579
            |.:...|..|...|. .:|:.|..|.:.|.....|.||.|:|
Mouse   576 FHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLSKHKRVH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	69/186 (37%)
		zf-C2H2	412..434	CDD:278523	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..451	CDD:290200	12/24 (50%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	16/23 (70%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
Zfp729a	NP_898969.2	KRAB	15..73	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	93..110	CDD:275368
		C2H2 Zn finger	121..141	CDD:275368
		C2H2 Zn finger	149..169	CDD:275368
		C2H2 Zn finger	177..197	CDD:275368
		zf-H2C2_2	190..213	CDD:290200
		C2H2 Zn finger	205..225	CDD:275368
		zf-H2C2_2	218..242	CDD:290200
		COG5048	229..670	CDD:227381	131/367 (36%)
		C2H2 Zn finger	233..253	CDD:275368
		zf-H2C2_2	246..269	CDD:290200	4/7 (57%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	302..324	CDD:290200	11/21 (52%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..421	CDD:275368	0/16 (0%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		zf-H2C2_2	470..492	CDD:290200	10/21 (48%)
		C2H2 Zn finger	485..505	CDD:275368	9/19 (47%)
		zf-H2C2_2	497..522	CDD:290200	17/24 (71%)
		COG5048	509..951	CDD:227381	39/115 (34%)
		C2H2 Zn finger	513..533	CDD:275368	9/19 (47%)
		zf-H2C2_2	525..550	CDD:290200	11/26 (42%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
		C2H2 Zn finger	597..617	CDD:275368	7/19 (37%)
		C2H2 Zn finger	626..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		zf-H2C2_2	694..717	CDD:290200
		C2H2 Zn finger	709..729	CDD:275368
		zf-H2C2_2	721..744	CDD:290200
		C2H2 Zn finger	737..757	CDD:275368
		zf-H2C2_2	749..773	CDD:290200
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		zf-H2C2_2	806..830	CDD:290200
		C2H2 Zn finger	821..841	CDD:275368
		C2H2 Zn finger	849..869	CDD:275368
		zf-H2C2_2	861..886	CDD:290200
		C2H2 Zn finger	877..897	CDD:275368
		zf-H2C2_2	890..914	CDD:290200
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	933..953	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000