DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and znf-782

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	471	Identity:	136/471 - (28%)
Similarity:	207/471 - (43%)	Gaps:	74/471 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DIDEPTDGKATNGQE---SEPLQEVFEITMNDIKTEDEVSIQETFEDAFDEENDNNNTDSEREDS 208
            |..:||....|...:   .:|.:|.||      :.|||: ::|  |:.||||.:      |.|:|
Worm     4 DYHQPTTTNTTLPDDIHMKDPEEEEFE------EYEDEL-LEE--EEEFDEELE------ELENS 53

  Fly   209 DQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHL 273
            |  :..|......|     .|..:..|::.|      ......|.......:.....|..:|.|:
Worm    54 D--SASSLVSAGSP-----HGSSSSNGSHGS------SPPLQVQSPSQGSGSSGSPTGQPEKRHI 105

  Fly   274 CDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFY 338
            |..||:||...:.|.:|:|.||||:|:.|..|.|.:....||:.|..||..|:.:||..|:|||.
Worm   106 CTVCGKGFSYFSILESHKRSHTGEKPYNCHFCQKTFAQKATLQVHERTHTGERPYKCRYCEKTFA 170

  Fly   339 TRGNLRAHIQ-RHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITH 402
            ..|....|.: .|.|.|.||||.|.:..:..|.|..|.:.| .::.|:|:.|.|.|....:|..|
Worm   171 QYGTKTVHEKSAHLGIRNYKCPKCDKLLSSPSALYTHKKTH-GDKTFRCDFCPKTFALKNYLKLH 234

  Fly   403 LR-VH-NGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGE 465
            :: || ..:|:..|..|:|.|....::..|.|||:|.:|:.|:.|.:||:...:|:||.|.||||
Worm   235 VKQVHEQNERKHVCVYCNKGFAYAGSLQVHVRTHTGERPYVCKFCPKAFASQGNLQSHERTHTGE 299

  Fly   466 KPYKCDQCGKGFSANQSLMKH-----TLWHVDNNDRP-------------------FKCSQCPKA 506
            :||.|..|.:.|.....|..|     |..|..|.|..                   ::|:.|.|.
Worm   300 RPYSCQFCQRTFIQKSQLTAHESTHLTQKHSVNPDSTTADILPVAGSVTDHQMVGNYECTFCNKK 364

  Fly   507 YDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKH-----------ITSHKIRPHPCP 560
            |....||..|.:.|..    |:.:.|..|...::.|.:|:.|           .|:.....|.|.
Worm   365 YPYASSLYIHMRKHTE----KSAYSCDGCGKPYSQKISLNIHQDQCEAFKNRLKTTDSQFSHNCD 425

  Fly   561 QCPEGFFSQKSLKKHL 576
            .|.:.|..:.:|:.|:
Worm   426 GCGKSFVQRIALQIHV 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	1/19 (5%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	11/23 (48%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/20 (35%)
		zf-H2C2_2	342..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/20 (30%)
		COG5048	<395..583	CDD:227381	59/219 (27%)
		zf-C2H2	412..434	CDD:278523	6/21 (29%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..451	CDD:290200	10/24 (42%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	4/15 (27%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	6/30 (20%)
		C2H2 Zn finger	559..579	CDD:275370	5/18 (28%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	8/19 (42%)
		zf-H2C2_2	119..143	CDD:290200	11/23 (48%)
		C2H2 Zn finger	134..154	CDD:275368	6/19 (32%)
		zf-H2C2_2	147..171	CDD:290200	11/23 (48%)
		C2H2 Zn finger	162..180	CDD:275368	7/17 (41%)
		COG5048	<187..404	CDD:227381	67/221 (30%)
		C2H2 Zn finger	191..211	CDD:275370	6/19 (32%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		zf-H2C2_2	260..285	CDD:290200	10/24 (42%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-H2C2_2	288..313	CDD:290200	13/24 (54%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..403	CDD:275368	4/16 (25%)
		C2H2 Zn finger	424..441	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000