DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and Zfp347

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_038934261.1	Gene:	Zfp347 / 170902	RGDID:	620185	Length:	740	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	139/389 - (35%)
Similarity:	201/389 - (51%)	Gaps:	58/389 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 YSTQKALARHVAKHKEQGDT-QKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHG 312
            |..:|..|.|....:.:..| :||:.|..||:.|.:...|.||.|.||||:|:.|..|.||:||.
  Rat   239 YQYEKDFAHHSCLQEHRTHTGEKPYECKQCGKAFGSRHYLKTHERIHTGEKPYACNQCGKAFTHY 303

  Fly   313 PTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFA---------KN 368
            .:|:.|...|..||.::|.||.|.|..|.||:.|...|.||:|::|..|.:.||         ::
  Rat   304 TSLRKHEKIHTGEKPYECSQCGKAFACRSNLQIHETSHKGEKPHECNQCGKAFAHIIYLQRHERS 368

  Fly   369 SG------------------LKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCP 415
            .|                  ||.|.:.|..|:|::|..|||.|.:...|..|.|:|.|::.::|.
  Rat   369 HGDKPYECNQCGKGFTQFGLLKKHYKNHTGEKPYECSQCGKAFARRNELQVHERIHTGEKPYECS 433

  Fly   416 DCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSAN 480
            .|.|:|..:||:..|:|||:|.||:.|.:||:||:...||:.|.|||||||||.|:||||.|:..
  Rat   434 QCGKAFTSRSNLQTHERTHTGEKPYLCNQCGKAFARRRHLQIHERIHTGEKPYTCNQCGKAFTHF 498

  Fly   481 QSLMKH----------------------TLWH----VDNNDRPFKCSQCPKAYDTQQSLRGHEKT 519
            .||..|                      |.:|    :...::|:.|.||.||:..:.:|:.||.:
  Rat   499 TSLHNHKKIHTGEKPYACNECGKTFTHFTSFHNHKKIHTGEKPYGCKQCGKAFSFRCNLKIHEAS 563

  Fly   520 HKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHKIRPHPCPQCPEGFFSQKSLKKHLRLHNLKK 583
            ||. ::|   |:|..|...||....|.:|..||..:|:.|.||.:||.....||.||:.|..:|
  Rat   564 HKG-EKP---HECNQCGKAFAHIVYLQRHERSHGDKPYECNQCGKGFTHFGRLKNHLKNHTGEK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	4/12 (33%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	13/23 (57%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		C2H2 Zn finger	330..350	CDD:275368	9/19 (47%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	8/46 (17%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	78/213 (37%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..451	CDD:290200	13/24 (54%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	17/23 (74%)
		C2H2 Zn finger	470..486	CDD:275368	8/15 (53%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	9/19 (47%)
Zfp347	XP_038934261.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	131..150	CDD:275368
		C2H2 Zn finger	159..176	CDD:275368
		C2H2 Zn finger	184..203	CDD:275368
		C2H2 Zn finger	212..230	CDD:275370
		C2H2 Zn finger	265..285	CDD:275368	8/19 (42%)
		zf-H2C2_2	277..302	CDD:404364	13/24 (54%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		zf-H2C2_2	305..330	CDD:404364	10/24 (42%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		C2H2 Zn finger	349..369	CDD:275368	4/19 (21%)
		COG5048	371..731	CDD:227381	90/257 (35%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		C2H2 Zn finger	460..480	CDD:275368	9/19 (47%)
		C2H2 Zn finger	488..508	CDD:275368	9/19 (47%)
		C2H2 Zn finger	516..536	CDD:275368	2/19 (11%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		C2H2 Zn finger	599..619	CDD:275368	9/19 (47%)
		C2H2 Zn finger	627..647	CDD:275368
		C2H2 Zn finger	655..675	CDD:275368
		C2H2 Zn finger	683..703	CDD:275368
		C2H2 Zn finger	711..731	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000