DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meics and ZNF266

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001357303.1	Gene:	ZNF266 / 10781	HGNCID:	13059	Length:	616	Species:	Homo sapiens

Alignment Length:	341	Identity:	128/341 - (37%)
Similarity:	191/341 - (56%)	Gaps:	11/341 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 ECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKA 308
            |||..:.....||..:..|:    ::||:.|..||:|||.:|.|..|...|||:.|::|..|.||
Human   255 ECGRGFIHSTDLAVRIQTHR----SEKPYKCKECGKGFRYSAYLNIHMGTHTGDNPYECKECGKA 315

  Fly   309 YTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKL 373
            :|....|..|..||..||.:||..|.:.|.....|..|::.|.||:||:|.:|...|.::|.|..
Human   316 FTRSCQLTQHRKTHTGEKPYKCKDCGRAFTVSSCLSQHMKIHVGEKPYECKECGIAFTRSSQLTE 380

  Fly   374 HSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIK 438
            |.:.|..:.||:|::|||.|..:..|..|.|:|.|.:.:||.||.|:|.:.|::.||.|||||.:
Human   381 HLKTHTAKDPFECKICGKSFRNSSCLSDHFRIHTGIKPYKCKDCGKAFTQNSDLTKHARTHSGER 445

  Fly   439 PFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQC 503
            |::|:|||:||:.:..|..|.|.||||||::|.:|||.|:.:.:|..|...|  ..::||:|.:|
Human   446 PYECKECGKAFARSSRLSEHTRTHTGEKPFECVKCGKAFAISSNLSGHLRIH--TGEKPFECLEC 508

  Fly   504 PKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFF 567
            .||:....||..|.:|| :..:|.|   |..|...|.....::.|:..|. .:|:.|.||.:.|.
Human   509 GKAFTHSSSLNNHMRTH-SAKKPFT---CMECGKAFKFPTCVNLHMRIHTGEKPYKCKQCGKSFS 569

  Fly   568 SQKSLKKHLRLHNLKK 583
            ...|.:.|.|.|..:|
Human   570 YSNSFQLHERTHTGEK 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	5/17 (29%)
		C2H2 Zn finger	274..294	CDD:275368	9/19 (47%)
		zf-H2C2_2	287..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	70/188 (37%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..451	CDD:290200	14/24 (58%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..478	CDD:290200	13/23 (57%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	532..552	CDD:275370	4/19 (21%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
ZNF266	NP_001357303.1	KRAB	39..95	CDD:214630
		C2H2 Zn finger	199..217	CDD:275370
		C2H2 Zn finger	225..245	CDD:275368
		C2H2 Zn finger	254..273	CDD:275368	5/17 (29%)
		COG5048	277..616	CDD:227381	122/315 (39%)
		C2H2 Zn finger	281..301	CDD:275368	9/19 (47%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..469	CDD:275368	9/19 (47%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	4/19 (21%)
		C2H2 Zn finger	561..581	CDD:275368	7/19 (37%)
		C2H2 Zn finger	589..609	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000