DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and si:ch211-191d2.2

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_009292950.1	Gene:	si:ch211-191d2.2 / 101882796	ZFINID:	ZDB-GENE-110407-3	Length:	499	Species:	Danio rerio

Alignment Length:	581	Identity:	165/581 - (28%)
Similarity:	253/581 - (43%)	Gaps:	129/581 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MERSVDASMGKNCRACAEHSSILVDLFSKEISDPPIWEMLNSILPEICRVKRD---------EMP 64
            ||..||.|..|         |:..||...:|.|         .|.:||::|::         |..
Zfish     8 MEVQVDVSCCK---------SVGTDLSMLDIED---------FLSQICQLKKEVASLEAKLRERG 54

  Fly    65 QKICP-----TCLVAAQNAFHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIV 124
            :|:.|     .|.|.||   .||                |..||:||
Zfish    55 EKLQPEHQDSMCGVRAQ---RFR----------------DTQNSDLS------------------ 82

  Fly   125 GCEDPLDTNVTKLDANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIK---------TED 180
                     :|.|      ..||..:....:...|::...| ::..|.:.|.:         ||:
Zfish    83 ---------LTLL------CYTDAQDHQSSEPNAGEQQTTL-KMCSIRLEDCRNLIQRTENITEE 131

  Fly   181 EVSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQ------- 238
            |...::..||  |.:||.|..|.:.::.|:      ::.|:.:||..   ..:|.:::
Zfish   132 EEDQRDQEED--DGDNDENGKDDDDDNDDE------DNNDDEFIPAD---DNIGSSDEEAPLTSK 185

  Fly   239 -------SLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTG 296
                   |..||.||.:::.|:.|..|..||.:    .|..:|..|.:.|.|..:...|::.|..
Zfish   186 DKRKSKKSFSCTSCGKAFACQRFLLFHEKKHSD----PKASVCWRCLKIFPTLQERKLHQKEHLA 246

  Fly   297 ERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDC 361
            ::.|.|..|.|.:.....||.|:.||..|:..:|..|:|:|..:..|..|.:.||||||||||.|
Zfish   247 KKEFHCEQCGKDFLSFSQLKGHLKTHSGEQRVQCDVCNKSFCNKQTLEVHKRIHTGERPYKCPHC 311

  Fly   362 PQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSN 426
            .::|...:.:|.|.|:|..||||:|..|||.|..|..|..||:.|:.::..:|..|:|.|.:|:.
Zfish   312 NKSFNYKAAMKNHIRIHTNERPFQCSECGKAFKTNYTLSCHLKFHSEEKPLQCKYCNKRFRQKAQ 376

  Fly   427 MMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHV 491
            :..|:|.|:|.||:.|.|||:....:..:..|.|.|||||||.|..||:.|:....|..|...|
Zfish   377 LNVHERIHTGEKPYLCAECGKRVKSSTEMVYHQRHHTGEKPYLCKICGRSFNKTSILKNHMRTH- 440

  Fly   492 DNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHCDVRFALKKTLDKHITSH 552
             ..|||:|||.|.|.:.....::.||:.|.. ::|   ::|..|..|||...:...|...|
Zfish   441 -TGDRPYKCSHCDKTFARLDVMKTHERVHTG-EKP---YRCSICGERFAYLGSFLSHQKKH 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	18/87 (21%)
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	6/23 (26%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	13/23 (57%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		COG5048	<395..583	CDD:227381	55/158 (35%)
		zf-C2H2	412..434	CDD:278523	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	10/24 (42%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	5/15 (33%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370
si:ch211-191d2.2	XP_009292950.1	COG5048	<196..359	CDD:227381	62/166 (37%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		zf-C2HE	<232..272	CDD:292895	10/39 (26%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..317	CDD:290200	14/23 (61%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	320..345	CDD:290200	13/24 (54%)
		COG5048	<333..492	CDD:227381	60/164 (37%)
		C2H2 Zn finger	336..356	CDD:275368	9/19 (47%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	433..457	CDD:290200	11/25 (44%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		zf-H2C2_2	461..485	CDD:290200	8/27 (30%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870