DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and si:cabz01032454.3

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_003198589.1	Gene:	si:cabz01032454.3 / 100534979	ZFINID:	ZDB-GENE-161017-73	Length:	499	Species:	Danio rerio

Alignment Length:	504	Identity:	164/504 - (32%)
Similarity:	234/504 - (46%)	Gaps:	93/504 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESEPL--QEVFEITMND-IKTEDEVSIQETFEDAFDEENDNNNTDSEREDSDQWTVGSTEDQDE 221
            :|||.|  ::.|.:...| .:||..|..:||.|....:|.|...|..:....:|.:...:.....
Zfish     6 EESEDLKIEDTFTVKQEDPEQTELMVLKEETQEMNEMKEKDQIETHQDLTTDEQSSCKRSPKTKS 70

  Fly   222 PWIPGGGGRQTVGGNNQSLL--------------CTECGVSYSTQKALARHVAKHKEQGDTQKPH 272
            .:|....|:   |.|:|..|              |.:||.|:|..:.|..|:..|.:    ::|:
Zfish    71 DFICSQCGK---GFNHQPNLIVHMRIHTGERPYSCDQCGKSFSQNEKLKVHMRVHTK----ERPY 128

  Fly   273 LCDFCGRGFRTNAQLTTHRRRHTGERPF----------------------------KCPLCPKAY 309
            .|..||:.|.....|..|.|.||||:||                            .|.:|.|.:
Zfish   129 TCPQCGKSFTQKESLNVHIRVHTGEKPFPCQHCGKRFSQLHALKEHVTIHTGERPHACTVCGKTF 193

  Fly   310 THGPTLKSHM------------------------------HT----HDEEKGHKCPQCDKTFYTR 340
            .|...|:.||                              ||    |.:||.:.|.:|||.|.::
Zfish   194 YHKQKLEKHMTVHTGEKLFDCQQCGKRFGQKDSLRIHMKLHTKDKPHAKEKPYICTECDKAFASK 258

  Fly   341 GNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRV 405
            .||..|:..||||:|:.|.:|.::|.:||.||:|.|:|.:|:|:.|:.|||.|.||:.|..|:||
Zfish   259 SNLNHHMVTHTGEKPFSCDECGKSFGQNSKLKVHMRVHTKEKPYSCDQCGKSFSQNEKLKVHMRV 323

  Fly   406 HNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKC 470
            |..:|.:.||.|.|||.:|.|:..|.|.|:|.|||.|:|||:.|...|.||.|||.||||||:.|
Zfish   324 HTKERPYTCPQCGKSFTQKENLKVHIRVHTGEKPFPCQECGKRFMQLHVLKEHLRTHTGEKPFAC 388

  Fly   471 DQCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQCPHC 535
            .||.|.:...|.|..|...|.  .::.|.|.||.|.:..:.||:.|.|.|.   |.|. |.|..|
Zfish   389 PQCSKTYCQKQKLKMHMTVHA--KEKLFPCQQCGKRFGYRGSLKSHMKLHA---EDKR-HTCSQC 447

  Fly   536 DVRFALKKTLDKHITSHKIRP-HPCPQCPEGFFSQKSLKKHLRLHNLKK 583
            ...|.:|..|:.|:.:|...| :.|.||.:.|..:..|..|:|.|..:|
Zfish   448 GEGFTMKSHLNSHMRTHSGEPSYSCTQCGKTFSRKYVLNCHMRTHTGEK 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..294	CDD:275368	7/19 (37%)
		zf-H2C2_2	287..311	CDD:290200	12/51 (24%)
		C2H2 Zn finger	302..322	CDD:275368	9/53 (17%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	9/19 (47%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		COG5048	<395..583	CDD:227381	77/188 (41%)
		zf-C2H2	412..434	CDD:278523	10/21 (48%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..451	CDD:290200	13/24 (54%)
		C2H2 Zn finger	442..462	CDD:275368	11/19 (58%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	6/15 (40%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)
si:cabz01032454.3	XP_003198589.1	COG5048	52..481	CDD:227381	144/441 (33%)
		C2H2 Zn finger	74..94	CDD:275368	5/22 (23%)
		zf-H2C2_2	86..111	CDD:290200	5/24 (21%)
		C2H2 Zn finger	102..122	CDD:275368	7/19 (37%)
		zf-H2C2_2	115..139	CDD:290200	8/27 (30%)
		C2H2 Zn finger	130..150	CDD:275368	7/19 (37%)
		zf-H2C2_2	142..167	CDD:290200	9/24 (38%)
		C2H2 Zn finger	158..178	CDD:275368	0/19 (0%)
		C2H2 Zn finger	186..206	CDD:275368	7/19 (37%)
		C2H2 Zn finger	214..234	CDD:275368	0/19 (0%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		zf-H2C2_2	260..283	CDD:290200	10/22 (45%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	289..313	CDD:290200	12/23 (52%)
		C2H2 Zn finger	304..324	CDD:275368	10/19 (53%)
		zf-H2C2_2	317..341	CDD:290200	12/23 (52%)
		C2H2 Zn finger	332..352	CDD:275368	10/19 (53%)
		zf-H2C2_2	344..367	CDD:290200	12/22 (55%)
		C2H2 Zn finger	360..380	CDD:275368	11/19 (58%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000