DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meics and si:cabz01069020.1

DIOPT Version :9

Sequence 1:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_002667484.1	Gene:	si:cabz01069020.1 / 100332930	ZFINID:	ZDB-GENE-161017-80	Length:	338	Species:	Danio rerio

Alignment Length:	360	Identity:	118/360 - (32%)
Similarity:	173/360 - (48%)	Gaps:	53/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QESEPLQ-------EVFEITMND---------IKTEDEVSIQETFEDAFDEENDNNNTD---SER 205
            :|||.::       |||.:...|         :|.|.||      ::..:|.|...|.|   .|:
Zfish     6 EESEDVKIEGLRIAEVFTLKHEDPEEQTGVMAVKMETEV------KNEMEETNQCKNPDLITGEK 64

  Fly   206 -----EDSDQWT-VGSTEDQDEPWIPGGGGRQTVGGNNQSLLCTECGVSYSTQKALARHVAKHKE 264
                 .|...|. |..|                  .:....:|.:||.|:.....|..|...|
Zfish    65 IFCLQPDRASWAKVKKT------------------ASRSYFICQQCGKSFKEPGKLKVHTRIH-- 109

  Fly   265 QGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKSHMHTHDEEKGHK 329
              :.:||:.|..||:.|.....||.|.|.||||:|:.|..|.|:::....|.:|:.||..||...
Zfish   110 --NGEKPYSCQHCGKCFDKKGNLTVHMRIHTGEKPYSCQHCGKSFSQKVFLTAHLRTHTGEKLCT 172

  Fly   330 CPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNSGLKLHSRLHKEERPFKCELCGKGFV 394
            ||||.|:|...|:|:.|::.||||:||.|..|.:.|.|...|.:|.|:|..|:|:.|:.|||.|.
Zfish   173 CPQCGKSFNMLGDLKVHMRIHTGEKPYACQHCGKCFNKQGNLTIHMRIHTGEKPYACQHCGKCFN 237

  Fly   395 QNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGIKPFKCEECGQAFSHNHHLKSHL 459
            :..:|..|:|||.|::.:.|..||.||.:|..:..|.:||:|...:.|::||:.|........|:
Zfish   238 KKGNLTVHMRVHTGEKPYACEHCDNSFSQKVFLTAHLKTHTGENSYTCQQCGKCFRAFGKFNVHM 302

  Fly   460 RIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNN 494
            ||||||:||.|.:|.|.|.:..:|..|...|...|
Zfish   303 RIHTGERPYSCQRCEKSFISKGNLTVHMRTHSGEN 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meics	NP_524062.1	zf-AD	21..95	CDD:285071
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	287..311	CDD:290200	12/23 (52%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	9/19 (47%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	37/100 (37%)
		zf-C2H2	412..434	CDD:278523	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..451	CDD:290200	8/24 (33%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	5/15 (33%)
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
si:cabz01069020.1	XP_002667484.1	COG5048	<78..234	CDD:227381	60/177 (34%)
		C2H2 Zn finger	89..109	CDD:275368	6/19 (32%)
		zf-C2H2	115..137	CDD:278523	8/21 (38%)
		C2H2 Zn finger	117..137	CDD:275368	8/19 (42%)
		zf-H2C2_2	129..154	CDD:290200	12/24 (50%)
		C2H2 Zn finger	145..165	CDD:275368	5/19 (26%)
		COG5048	<169..322	CDD:227381	64/152 (42%)
		C2H2 Zn finger	173..193	CDD:275368	9/19 (47%)
		zf-H2C2_2	185..209	CDD:290200	10/23 (43%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		zf-H2C2_2	213..237	CDD:290200	10/23 (43%)
		C2H2 Zn finger	229..249	CDD:275368	8/19 (42%)
		zf-H2C2_2	241..266	CDD:290200	11/24 (46%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..300	CDD:275368	4/14 (29%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100488
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810