DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32137 and SLK19

DIOPT Version :9

Sequence 1:	NP_729935.1	Gene:	CG32137 / 39537	FlyBaseID:	FBgn0052137	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_014838.3	Gene:	SLK19 / 854370	SGDID:	S000005721	Length:	821	Species:	Saccharomyces cerevisiae

Alignment Length:	495	Identity:	101/495 - (20%)
Similarity:	191/495 - (38%)	Gaps:	140/495 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LQQKE---SDILLAAELGKALLEKNEELVKQQEKLIEDYSSKI----EKLEQEKHVLRQK----- 162
            |||.|   :|..:..|..||.|:.|.:.:.:.|..:.|.:|:|    :|:|....||:.|
Yeast   422 LQQNEKILNDKNVELENMKAELKGNNDKLSEYETTLNDLNSRIVQLNDKIESTDIVLKSKENELD 486

  Fly   163 ---------LAIAEDESDQRVLELQSDLTELKDKLQTQDTAIRQAEKEKTILIDELQHQNTRLTE 218
                     |:|::|.:|..::...::|...|:.||           :|...::.|...|.::.:
Yeast   487 NLKLSLKETLSISKDFNDSDLIGQINELISTKNNLQ-----------QKMDDLNNLNDDNLKVVQ 540

  Fly   219 Q--IQEAHATELK------LSAQIQELKDQYHYRNSSLQEHVNSLESIKTELNLTTGKRQELERR 275
            .  |:.....:||      |::::.|||.|...::...:...:..|:::.|..:...:..||...
Yeast   541 DKLIKNEETLKLKEAEIDSLNSEMDELKKQITSKDDEFKMWQSKYETVEDEAKIRNAEVTELNGD 605

  Fly   276 LQIAQEEKESLTSSLEESSDRIHMLERHAREQETKLETTLQALERSQREN-NVLSERLGADTNSS 339
            ::..:|.|..|..::.|..:::|.||.....::.|.|.|...||..|.:| |:.:|.:
Yeast   606 IEDLKESKLHLEETITELENKVHKLENECELEKQKFEKTSLELESLQLKNSNIQAEHI------- 663

  Fly   340 TPGRKSLQFEMECDEDDGSYTETGKPNQMFVEARSVYIQLKSLVDSLKVSHDDDSGLNSDISLEL 404
                                          .|..:::..|.||.:.||:|.|..:.|..:..:.:
Yeast   664 ------------------------------KELENLHENLISLQNELKISSDRITTLTKENEVLM 698

  Fly   405 ESMDN-----TISSSERHEDGHLAIEFRQGMLSSMSDELTRLLLNLDAGNFKKMLDQTRNLVLEQ 464
            |..:|     |:|:.::..|                ||..:.|       .|::.|.......::
Yeast   699 EQNNNNNNSVTLSNDQKDRD----------------DEKIKSL-------GKQVQDWKEKYEAKE 740

  Fly   465 EDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARGDLEDNTDRDELLSKA-----QTERDAAN 524
            :|..||         .|:...|:.:|...:...:.:           ||.|.     |.:.|..|
Yeast   741 KDTNKR---------LKLLAEDLYIQYSSKHEQKVK-----------LLKKGYENKYQNKFDQLN 785

  Fly   525 -DRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLE 563
             :.:|.:|        |:.|.|.||....::|.||.:.||
Yeast   786 LENKTLSE--------EIEQLNKQLSSEREEKQELLKLLE 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32137	NP_729935.1	DUF4337	<105..>172	CDD:290935	22/82 (27%)
SLK19	NP_014838.3	PTZ00482	25..>185	CDD:240433
		SMC_prok_B	<249..623	CDD:274008	45/211 (21%)
		Smc	<462..821	CDD:224117	89/455 (20%)
		Kinetocho_Slk19	742..818	CDD:403801	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5574
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950