DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32137 and bicdl1

DIOPT Version :9

Sequence 1:	NP_729935.1	Gene:	CG32137 / 39537	FlyBaseID:	FBgn0052137	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	XP_031757461.1	Gene:	bicdl1 / 779781	XenbaseID:	XB-GENE-5811431	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	171/532 - (32%)
Similarity:	292/532 - (54%)	Gaps:	62/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 GDSIDLEHYISAMEARRHDQEPDVWAQLQQKESDILLAAELGKALLEKNEELVKQQEKLIEDYSS 147
            ||..::|    ..|.|   ::.::...::|||.|::|||.|||||||:|:::.::.|::..:.:.
Frog    46 GDPEEIE----GPEVR---EQSELLCIIRQKEKDLVLAARLGKALLERNQDMSRRYEEMQREMTD 103

  Fly   148 KIEKLEQEKHVLRQKLAIAEDESDQRVLELQSDLTELKDKLQTQDTAIRQAEKEKTILIDELQHQ 212
            |:|.||||||.|::||...|.|.:.||.||:||:..|:::|:.|...:|:|::||..::.||..|
Frog   104 KLEHLEQEKHELKRKLENREGEWEGRVSELESDVKLLQEELEKQQVNLREADREKLSVVQELSEQ 168

  Fly   213 NTRLTEQIQEAHATELKLSAQIQELKDQYHYRNSSLQEHVNSLESIKT----ELNLTTGKRQELE 273
            |.||.||:..|...|.:||.|:..|::::..::.|..:||:.|||:..    |:.:.:.:::|||
Frog   169 NQRLLEQLSRATEMERQLSQQVNVLQEEFREKSLSTSQHVSRLESLLAEQILEIKMLSDRKRELE 233

  Fly   274 RRLQIAQEEKESLTSSLEESSDRIHMLE-----RHAREQETKLETTLQALERSQRENNVLSERLG 333
            ::|....||.|.|...:||..|:...|.     :..:.:|::||.....|...|.|..:  |.|.
Frog   234 QQLSTIMEENEQLQGLVEELQDKELSLNQQNFGKDLQLRESQLEIEEMRLSYRQLEGKL--EELR 296

  Fly   334 AD------TNSSTPGRKSLQFEMECDEDDGSYTETGKPNQMFVEARSVYIQLKSLVDSLKVSHDD 392
            .:      .::||.....::..:|.:|.:      .:..|:.::....:.|::||...|:.:...
Frog   297 EEKSLQHMNSTSTSLLSEIEQSIEAEEQE------QEREQLRLQLWEAHCQVRSLCCQLRGNESA 355

  Fly   393 DSGLNSDISLELESMDNTISSSERHEDGHLAIEFRQGMLSSMSDELTRLLLNL----DAGNFKKM 453
            ||.:::|     .|||.:..:|.       |.:...|.|.:...||..|:|::    |:.:.:|.
Frog   356 DSAVSTD-----SSMDESSETSS-------AKDVPAGSLRTALSELKSLILSILETCDSASSRKC 408

  Fly   454 LD--------QT-------RNLVLEQEDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARGDL 503
            .|        ||       |.|:..::..:|::...:|:|..:||:..||:..:|||||:.. .|
Frog   409 EDDGLEEQIKQTSEDSRALRELLQGEQMRMKQTFDELQELHKQVTLLSVEMNALKEERDRLL-VL 472

  Fly   504 EDNTDRDELLSKAQTERDAANDRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLEQWQMD 568
            ..|.:..|.|.||..:||.|..::|..|:||||.|::||..|:|||::||||:.||||||.||.|
Frog   473 TQNDETQEQLMKAIKDRDEAISKKTAVELELAKCRIDLMSLNTQLLDAIQQKLNLSQQLEAWQDD 537

  Fly   569 MHELIDEQMRSK 580
            ||.:||:|:..|
Frog   538 MHRVIDQQLMDK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32137	NP_729935.1	DUF4337	<105..>172	CDD:290935	29/66 (44%)
bicdl1	XP_031757461.1	SbcC	<49..>533	CDD:223496	159/511 (31%)
bicdl1	XP_031757461.1	SMC_prok_A	<81..>300	CDD:274009	74/220 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2036
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18013
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3125
OMA	1	1.010	-	-		QHG46829
OrthoDB	1	1.010	-	-		D269681at33208
OrthoFinder	1	1.000	-	-		FOG0002987
OrthoInspector	1	1.000	-	-		oto105384
Panther	1	1.100	-	-	O	PTHR32123
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4483
SonicParanoid	1	1.000	-	-		X5076
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110