Protein Alignment CG32137 and BICDL2

DIOPT Version :9

• Sequence 1: NP_729935.1
• Gene: CG32137 / 39537
• FlyBaseID: FBgn0052137
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001096645.1
• Gene: BICDL2 / 146439
• HGNCID: 33584
• Length: 508
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 168/578 - (29%)
• Similarity: 270/578 - (46%)
• Gaps: 96/578 - (16%)

  Fly    58 TGAGAGGLLRSDDSGFDHLDYSSLIGDSIDLEHYISAMEARRHDQEP-DVWAQLQQKESDILLAA 121
            :|..:||...|.|.||          ....||...|.:......:|| |:..||||||.|:||||
Human    11 SGPLSGGASPSGDEGF----------FPFVLERRDSFLGGGPGPEEPEDLALQLQQKEKDLLLAA 65

  Fly   122 ELGKALLEKNEELVKQQEKLIEDYSSKIEKLEQEKHVLRQKLAIAEDESDQRVLELQSDLTELKD 186
            ||||.|||:||||.:|.|.|...:..:.|:|:||.|.||:.||....|.:.|.:||:.|:..|:.
Human    66 ELGKMLLERNEELRRQLETLSAQHLEREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA 130

  Fly   187 KLQTQDTAIRQAEKEKTILIDELQHQNTRLTEQIQEAHATELKLSAQIQELKDQYHYRNSSLQEH 251
            :|..|.:..:.:.:|:...:.||..||.||::|:.:|..||.:|..::..|:.|...:..:..|.
Human   131 QLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAEL 195

  Fly   252 VNSLESIKTELNLTTGKRQELERRLQIAQEEKESLTSSLEESSDRIHMLERHAREQETKLE---- 312
            ...|||::.|..:...:||:||.:::..:||.|.....|:.:.:.:.:|.|..||...:||
Human   196 RTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARS 260

  Fly   313 ---TTLQALERSQRENNVLSE--RL-GADTNSSTPGRKSLQFEMECDEDDGSYTETGKPNQMFVE 371
               ..|.||.|.||..:.|.|  || .||.:::     |||.|:....|||
Human   261 EAGEALSALRRLQRRVSELEEESRLQDADVSAA-----SLQSELAHSLDDG-------------- 306

  Fly   372 ARSVYIQLKSLVDSLKVSHDDDSGLNSDISLELESMDNTISSSERHEDGHLAIEFRQGMLSSMSD 436
                                 |.|..:|...:..:   |.|...|             ..||...
Human   307 ---------------------DQGQGADAPGDTPT---TRSPKTR-------------KASSPQP 334

  Fly   437 ELTRLLLNLDAGNFKKMLDQTRNLVLEQEDEIKRSHQLIQQLEAKVTVTDVELQNVKEERDQARG 501
            .....:|...    ||....:...:|| |.|::     :.:|:.::::...|||:::||. |.:.
Human   335 SPPEEILEPP----KKRTSLSPAEILE-EKEVE-----VAKLQDEISLQQAELQSLREEL-QRQK 388

  Fly   502 DLEDNTDRDELLSKAQTERDAANDRRTKAEVELAKTRVELMQANSQLLESIQQKVELSQQLEQWQ 566
            :|....|..|.|..|.::||.|.::..:..::|.:..:|....:.:||.:|:|||.|:|:||.||
Human   389 ELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQ 453

  Fly   567 MDMHELIDEQMRSKLINNRRAMAAESSAPSPPSSAAANLAKRV----TSYKLWSLFQR 620
            .||..:|.:|:||:    |:...:.|::.|.|..||...:.|:    ....|.:||:|
Human   454 DDMQVVIGQQLRSQ----RQKELSASASSSTPRRAAPRFSLRLGPGPAGGFLSNLFRR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32137	NP_729935.1	DUF4337	<105..>172	CDD:290935	36/66 (55%)
BICDL2	NP_001096645.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/25 (28%)
		SMC_prok_B	<53..>296	CDD:274008	88/247 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..152		3/19 (16%)
		Smc	<192..>450	CDD:224117	78/324 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..351		14/105 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..491		5/20 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWXB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D269681at33208
OrthoFinder	1	1.000	-	-		FOG0002987
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR32123
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4483
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.840